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The Journal of Neuroscience, February 11, 2004, 24(6):1265-1271; doi:10.1523/JNEUROSCI.3823-03.2004
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Behavioral/Systems/Cognitive
Dopamine Operates as a Subsecond Modulator of Food Seeking
Mitchell F. Roitman,1 Garret D. Stuber,2 Paul E. M. Phillips,1,3 R. Mark Wightman,2,3 andRegina M. Carelli1,2 1Department of Psychology, 2Curriculum in Neurobiology, 3Department of Chemistry and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
The dopamine projection to the nucleus accumbens has been implicated in behaviors directed toward the acquisition and consumption of natural rewards. The neurochemical studies that established this link made time-averaged measurements over minutes, and so the precise temporal relationship between dopamine changes and these behaviors is not known. To resolve this, we sampled dopamine every 100 msec using fast-scan cyclic voltammetry at carbon-fiber microelectrodes in the nucleus accumbens of rats trained to press a lever for sucrose. Cues that signal the opportunity to respond for sucrose evoked dopamine release (67 ± 20 nM) with short latency (0.2 ± 0.1 sec onset). When the same cues were presented to rats naive to the cue-sucrose pairing, similar dopamine signals were not observed. Thus, cue-evoked increases in dopamine in trained rats reflected a learned association between the cues and sucrose availability. Lever presses for sucrose occurred at the peak of the dopamine surges. After lever presses, and while sucrose was delivered and consumed, no further increases in dopamine were detected. Rather, dopamine returned to baseline levels. Together, the results strongly implicate subsecond dopamine signaling in the nucleus accumbens as a real-time modulator of food-seeking behavior.
Key words: accumbens; dopamine; feeding; motivation; reward; taste
Received Aug 15, 2003; revised November 13, 2003; accepted December 8, 2003.
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