 |
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, February 11, 2004, 24(6):1416-1427; doi:10.1523/JNEUROSCI.4111-03.2004
Previous Article | Next Article
Behavioral/Systems/Cognitive
Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity
Subimal Datta, Vijayakumar Mavanji, Jagadish Ulloor, andElissa H. Patterson Sleep Research Laboratory, Department of Psychiatry and Program in Behavioral Neuroscience, Boston University School of Medicine, Boston, Massachusetts 02118
Animal and human studies of sleep and learning have demonstrated that training on various tasks increases subsequent rapid eye movement (REM) sleep and phasic pontine-wave (P-wave) activity, followed by improvement in performance on the learned task. It is well documented that REM sleep deprivation after learning trials blocks the expected improvement in performance on subsequent retesting. Our aim was to test whether experimentally induced P-wave generator activation could eliminate the learning impairment produced by post-training REM sleep deprivation. Rats were trained on a two-way active avoidance-learning task. Immediately thereafter, two groups of those rats received a control vehicle (100 nl saline) microinjection and one group received a carbachol (50 ng in 100 nl saline) microinjection into the P-wave generator. The carbachol-injected group and one of the two control saline microinjected groups were selectively deprived of REM sleep during a 6 hr polygraphic recording session. All rats were then tested on the avoidance-learning task. The rats that received both the control saline injection and REM sleep deprivation showed learning deficits compared with the control saline-injected rats that were allowed to sleep normally. In contrast, the rats that received the carbachol microinjection and REM sleep deprivation demonstrated normal learning. These results demonstrate, for the first time, that carbachol-induced activation of the P-wave generator prevents the memory-impairing effects of post-training REM sleep deprivation. This evidence supports our hypothesis that the activation of the P-wave generator during REM sleep deprivation enhances a physiological process of memory, which occurs naturally during post-training REM sleep.
Key words: pontine wave; learning and memory; REM sleep; plasticity; carbachol; brainstem; locus subcoeruleus; rat; two-way active avoidance; consolidation
Received June 18, 2003; revised December 18, 2003; accepted December 19, 2003.
This article has been cited by other articles:
S. M. Montgomery, A. Sirota, and G. Buzsaki
Theta and Gamma Coordination of Hippocampal Networks during Waking and Rapid Eye Movement Sleep
J. Neurosci., June 25, 2008; 28(26): 6731 - 6741.
[Abstract] [Full Text] [PDF]
S. Datta
Activation of Pedunculopontine Tegmental PKA Prevents GABAB Receptor Activation-Mediated Rapid Eye Movement Sleep Suppression in the Freely Moving Rat
J Neurophysiol, June 1, 2007; 97(6): 3841 - 3850.
[Abstract] [Full Text] [PDF]
R. S. Bandyopadhya, S. Datta, and S. Saha
Activation of pedunculopontine tegmental protein kinase a: a mechanism for rapid eye movement sleep generation in the freely moving rat.
J. Neurosci., August 30, 2006; 26(35): 8931 - 8942.
[Abstract] [Full Text] [PDF]
S. K. Jha, B. E. Jones, T. Coleman, N. Steinmetz, C.-T. Law, G. Griffin, J. Hawk, N. Dabbish, V. A. Kalatsky, and M. G. Frank
Sleep-Dependent Plasticity Requires Cortical Activity
J. Neurosci., October 5, 2005; 25(40): 9266 - 9274.
[Abstract] [Full Text] [PDF]
K. A. Paller and J. L. Voss
Memory reactivation and consolidation during sleep
Learn. Mem., November 1, 2004; 11(6): 664 - 670.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|