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The Journal of Neuroscience, February 18, 2004, 24(7):1561-1564; doi:10.1523/JNEUROSCI.4650-03.2004

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BRIEF COMMUNICATION
Decreased Phosphorylation of NMDA Receptor Type 1 at Serine 897 in Brains of Patients with Schizophrenia

Effat S. Emamian,^1,2 Maria Karayiorgou,¹ and Joseph A. Gogos²

¹The Rockefeller University, Laboratory of Human Neurogenetics, New York, New York 10021, and ²Columbia University, College of Physicians and Surgeons, Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, New York, New York 10032

NMDA receptor hypofunction in schizophrenia has been inferred by a large number of clinical and preclinical observations; however, whether and how NMDA receptors are exactly involved in the pathogenesis of schizophrenia are still unknown and subject to interpretation. Here we show, in two independent samples of brains from patients with schizophrenia, a significant decrease in the phosphorylation level at serine 897 (S897) of the NMDA receptor type 1 (NR1) subunit. Our finding, together with a previous report that antipsychotics increase phosphorylation of NR1 at S897 in vivo, strongly suggests that insufficient phosphorylation at S897 may contribute to the neuronal pathology underlying schizophrenia.

Key words: schizophrenia; NMDA receptors; NR1; phosphorylation; serine 897; postmortem

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Received Oct 14, 2003; revised December 23, 2003; accepted December 27, 2003.

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