QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, February 18, 2004, 24(7):1707-1718; doi:10.1523/JNEUROSCI.4846-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (60) Citing Articles via Google Scholar Google Scholar Articles by McRory, J. E. Articles by Snutch, T. P. Search for Related Content PubMed PubMed Citation Articles by McRory, J. E. Articles by Snutch, T. P.

 Previous Article  |  Next Article 

Cellular/Molecular
The CACNA1F Gene Encodes an L-Type Calcium Channel with Unique Biophysical Properties and Tissue Distribution

John E. McRory,¹ Jawed Hamid,² Clinton J. Doering,^2,3 Esperanza Garcia,¹ Robin Parker,⁴ Kevin Hamming,¹ Lina Chen,² Michael Hildebrand,¹ Aaron M. Beedle,² Laura Feldcamp,² Gerald W. Zamponi,² and Terrance P. Snutch¹

¹Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3, ²Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1, ³NeuroMed Technologies Inc., Vancouver, British Columbia, Canada V6T 1Z4, and ⁴Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada V5Z 1M9

Glutamate release from rod photoreceptors is dependent on a sustained calcium influx through L-type calcium channels. Missense mutations in the CACNA1F gene in patients with incomplete X-linked congenital stationary night blindness implicate the Ca_v1.4 calcium channel subtype. Here, we describe the functional and pharmacological properties of transiently expressed human Ca_v1.4 calcium channels. Ca_v1.4 is shown to encode a dihydropyridine-sensitive calcium channel with unusually slow inactivation kinetics that are not affected by either calcium ions or by coexpression of ancillary calcium channel subunits. Additionally, the channel supports a large window current and activates near -40 mV in 2 mM external calcium, making Ca_v1.4 ideally suited for tonic calcium influx at typical photoreceptor resting potentials. Introduction of base pair changes associated with four incomplete X-linked congenital night blindness mutations showed that only the G369D alteration affected channel activation properties. Immunohistochemical analyses show that, in contrast with previous reports, Ca_v1.4 is widely distributed outside the retina, including in the immune system, thus suggesting a broader role in human physiology.

Key words: calcium channel; retina; night blindness; channelopathies; mast cells; plasma cells

---

Received Oct 28, 2003; revised December 1, 2003; accepted December 2, 2003.

This article has been cited by other articles:

				D. Specht, S.-B. Wu, P. Turner, P. Dearden, F. Koentgen, U. Wolfrum, M. Maw, J. H. Brandstatter, and S. tom Dieck Effects of Presynaptic Mutations on a Postsynaptic Cacna1s Calcium Channel Colocalized with mGluR6 at Mouse Photoreceptor Ribbon Synapses Invest. Ophthalmol. Vis. Sci., February 1, 2009; 50(2): 505 - 515. [Abstract] [Full Text] [PDF]

				A. A. Karaczyn, R. Y. S. Cheng, G. S. Buzard, J. Hartley, D. Esposito, and K. S. Kasprzak Truncation of Histone H2A's C-terminal Tail, as Is Typical for Ni(II)-Assisted Specific Peptide Bond Hydrolysis, Has Gene Expression Altering Effects Ann. Clin. Lab. Sci., January 1, 2009; 39(3): 251 - 262. [Abstract] [Full Text] [PDF]

				M. E. Mangoni and J. Nargeot Genesis and Regulation of the Heart Automaticity Physiol Rev, July 1, 2008; 88(3): 919 - 982. [Abstract] [Full Text] [PDF]

				S. Lee, O. Briklin, H. Hiel, and P. Fuchs Calcium-dependent inactivation of calcium channels in cochlear hair cells of the chicken J. Physiol., September 15, 2007; 583(3): 909 - 922. [Abstract] [Full Text] [PDF]

				M. A. Diana, Y. Otsu, G. Maton, T. Collin, M. Chat, and S. Dieudonne T-Type and L-Type Ca2+ Conductances Define and Encode the Bimodal Firing Pattern of Vestibulocerebellar Unipolar Brush Cells J. Neurosci., April 4, 2007; 27(14): 3823 - 3838. [Abstract] [Full Text] [PDF]

				H. W. Tedford and G. W. Zamponi Direct G Protein Modulation of Cav2 Calcium Channels Pharmacol. Rev., December 1, 2006; 58(4): 837 - 862. [Abstract] [Full Text] [PDF]

				P. S. Yang, B. A. Alseikhan, H. Hiel, L. Grant, M. X. Mori, W. Yang, P. A. Fuchs, and D. T. Yue Switching of Ca2+-Dependent Inactivation of CaV1.3 Channels by Calcium Binding Proteins of Auditory Hair Cells. J. Neurosci., October 18, 2006; 26(42): 10677 - 10689. [Abstract] [Full Text] [PDF]

				C. Wahl-Schott, L. Baumann, H. Cuny, C. Eckert, K. Griessmeier, and M. Biel Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain PNAS, October 17, 2006; 103(42): 15657 - 15662. [Abstract] [Full Text] [PDF]

				G. Baroudi, Y. Qu, O. Ramadan, M. Chahine, and M. Boutjdir Protein kinase C activation inhibits Cav1.3 calcium channel at NH2-terminal serine 81 phosphorylation site. Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1614 - H1622. [Abstract] [Full Text] [PDF]

				R Jalkanen, M Mantyjarvi, R Tobias, J Isosomppi, E-M Sankila, T Alitalo, and N T Bech-Hansen X linked cone-rod dystrophy, CORDX3, is caused by a mutation in the CACNA1F gene J. Med. Genet., August 1, 2006; 43(8): 699 - 704. [Abstract] [Full Text] [PDF]

				F. Mansergh, N. C. Orton, J. P. Vessey, M. R. Lalonde, W. K. Stell, F. Tremblay, S. Barnes, D. E. Rancourt, and N. T. Bech-Hansen Mutation of the calcium channel gene Cacna1f disrupts calcium signaling, synaptic transmission and cellular organization in mouse retina Hum. Mol. Genet., October 15, 2005; 14(20): 3035 - 3046. [Abstract] [Full Text] [PDF]

				A. Hemara-Wahanui, S. Berjukow, C. I. Hope, P. K. Dearden, S.-B. Wu, J. Wilson-Wheeler, D. M. Sharp, P. Lundon-Treweek, G. M. Clover, J.-C. Hoda, et al. A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Cav1.4 channel activation PNAS, May 24, 2005; 102(21): 7553 - 7558. [Abstract] [Full Text] [PDF]

				I. Vitko, Y. Chen, J. M. Arias, Y. Shen, X.-R. Wu, and E. Perez-Reyes Functional Characterization and Neuronal Modeling of the Effects of Childhood Absence Epilepsy Variants of CACNA1H, a T-Type Calcium Channel J. Neurosci., May 11, 2005; 25(19): 4844 - 4855. [Abstract] [Full Text] [PDF]

				D. Cia, A. Bordais, C. Varela, V. Forster, J. A. Sahel, A. Rendon, and S. Picaud Voltage-Gated Channels and Calcium Homeostasis in Mammalian Rod Photoreceptors J Neurophysiol, March 1, 2005; 93(3): 1468 - 1475. [Abstract] [Full Text] [PDF]

				J.-C. Hoda, F. Zaghetto, A. Koschak, and J. Striessnig Congenital Stationary Night Blindness Type 2 Mutations S229P, G369D, L1068P, and W1440X Alter Channel Gating or Functional Expression of Cav1.4 L-type Ca2+ Channels J. Neurosci., January 5, 2005; 25(1): 252 - 259. [Abstract] [Full Text] [PDF]

				D. Lipscombe, T. D. Helton, and W. Xu L-Type Calcium Channels: The Low Down J Neurophysiol, November 1, 2004; 92(5): 2633 - 2641. [Abstract] [Full Text] [PDF]

				Z. Z. Tang, M. C. Liang, S. Lu, D. Yu, C. Y. Yu, D. T. Yue, and T. W. Soong Transcript Scanning Reveals Novel and Extensive Splice Variations in Human L-type Voltage-gated Calcium Channel, Cav1.2 {alpha}1 Subunit J. Biol. Chem., October 22, 2004; 279(43): 44335 - 44343. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help