QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, March 3, 2004, 24(9):2236-2246; doi:10.1523/JNEUROSCI.4464-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Sedel, F. Articles by Triller, A. Search for Related Content PubMed PubMed Citation Articles by Sedel, F. Articles by Triller, A.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Macrophage-Derived Tumor Necrosis Factor , an Early Developmental Signal for Motoneuron Death

Frédéric Sedel, Catherine Béchade, Sheela Vyas, and Antoine Triller

Laboratoire de Biologie Cellulaire de la Synapse Normale et Pathologique, Institut National de la Santé et de la Recherche Médicale Unité 497, Ecole Normale Supérieure, 75005 Paris, France

Mechanisms inducing neuronal death at defined times during embryogenesis remain enigmatic. We show in explants that a developmental switch occurs between embryonic day 12 (E12) and E13 in rats that is 72-48 hr before programmed cell death. Half the motoneurons isolated from peripheral tissues at E12 escape programmed cell death, whereas 90% of motoneurons isolated at E13 enter a death program. The surrounding somite commits E12 motoneurons to death. This effect requires macrophage cells, is mimicked by tumor necrosis factor (TNF), and is inhibited by anti-TNF antibodies. In vivo, TNF is detected within somite macrophages, and TNF receptor 1 (TNFR1) is detected within motoneurons precisely between E12 and E13. Although motoneuron cell death occurs normally in TNF^-/- mice, this process is significantly reduced in explants from TNF^-/- and TNFR1 ^-/- mice. Thus, embryonic motoneurons acquire the competence to die, before the onset of programmed cell death, from extrinsic signals such as macrophage-derived TNF

Key words: motoneuron; macrophages; somite; TNF; apoptosis; developmental death

---

Received Oct 1, 2003; revised December 18, 2003; accepted December 21, 2003.

This article has been cited by other articles:

				S. Wakselman, C. Bechade, A. Roumier, D. Bernard, A. Triller, and A. Bessis Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor J. Neurosci., August 6, 2008; 28(32): 8138 - 8143. [Abstract] [Full Text] [PDF]

				A.-L. Mahul-Mellier, F. J. Hemming, B. Blot, S. Fraboulet, and R. Sadoul Alix, Making a Link between Apoptosis-Linked Gene-2, the Endosomal Sorting Complexes Required for Transport, and Neuronal Death In Vivo J. Neurosci., January 11, 2006; 26(2): 542 - 549. [Abstract] [Full Text] [PDF]

				A. Bessis, D. Bernard, and A. Triller Tumor Necrosis Factor-{alpha} and Neuronal Development Neuroscientist, August 1, 2005; 11(4): 277 - 281. [Abstract] [PDF]

				A. Bellucci, A. J. Westwood, E. Ingram, F. Casamenti, M. Goedert, and M. G. Spillantini Induction of Inflammatory Mediators and Microglial Activation in Mice Transgenic for Mutant Human P301S Tau Protein Am. J. Pathol., November 1, 2004; 165(5): 1643 - 1652. [Abstract] [Full Text] [PDF]

				Y.-A. Barde Death of injured neurons caused by the precursor of nerve growth factor PNAS, April 20, 2004; 101(16): 5703 - 5704. [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help