QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, March 9, 2005, 25(10):2513-2517; doi:10.1523/JNEUROSCI.5298-04.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (21) Citing Articles via Google Scholar Google Scholar Articles by Best, A. R. Articles by Wilson, D. A. Search for Related Content PubMed PubMed Citation Articles by Best, A. R. Articles by Wilson, D. A.

 Previous Article  |  Next Article 

BRIEF COMMUNICATION
Cortical Metabotropic Glutamate Receptors Contribute to Habituation of a Simple Odor-Evoked Behavior

Aaron R. Best, Jason V. Thompson, Max L. Fletcher, and Donald A. Wilson

Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019

Defining the circuits that are involved in production and cessation of specific behaviors is an ultimate goal of neuroscience. Short-term behavioral habituation is the response decrement observed in many behaviors that occurs during repeated presentation of non-reinforced stimuli. Within a number of invertebrate models of short-term behavioral habituation, depression of a defined synapse has been implicated as the mechanism. However, the synaptic mechanisms of short-term behavioral habituation have not been identified within mammals. We have shown previously that a presynaptic metabotropic glutamate receptor (mGluR)-dependent depression of synapses formed by olfactory bulb afferents to the piriform (olfactory) cortex significantly contributes to adaptation of cortical odor responses. Here we show that blockade of mGluRs within the olfactory cortex of awake, behaving rats diminishes habituation of a simple odor-induced behavior, strongly implicating a central mechanism for sensory gating in olfaction.

Key words: sensory habituation; memory; odor coding; metabotropic glutamate receptor; piriform cortex; adaptation

---

Received Nov 19, 2004; revised January 25, 2005; accepted February 1, 2005.

This article has been cited by other articles:

				R. M. Hallock, C. J. Martyniuk, and T. E. Finger Group III Metabotropic Glutamate Receptors (mGluRs) Modulate Transmission of Gustatory Inputs in the Brain Stem J Neurophysiol, July 1, 2009; 102(1): 192 - 202. [Abstract] [Full Text] [PDF]

				C. Linster, A. V. Menon, C. Y. Singh, and D. A. Wilson Odor-specific habituation arises from interaction of afferent synaptic adaptation and intrinsic synaptic potentiation in olfactory cortex Learn. Mem., June 24, 2009; 16(7): 452 - 459. [Abstract] [Full Text] [PDF]

				D. A. Wilson and C. Linster Neurobiology of a Simple Memory J Neurophysiol, July 1, 2008; 100(1): 2 - 7. [Abstract] [Full Text] [PDF]

				A. M. McNamara, P. D. Magidson, C. Linster, D. A. Wilson, and T. A. Cleland Distinct neural mechanisms mediate olfactory memory formation at different timescales Learn. Mem., February 22, 2008; 15(3): 117 - 125. [Abstract] [Full Text] [PDF]

				J. B. Castro, K. R. Hovis, and N. N. Urban Recurrent Dendrodendritic Inhibition of Accessory Olfactory Bulb Mitral Cells Requires Activation of Group I Metabotropic Glutamate Receptors J. Neurosci., May 23, 2007; 27(21): 5664 - 5671. [Abstract] [Full Text] [PDF]

				A. Bespalov, A.-L. Jongen-Relo, M. van Gaalen, S. Harich, H. Schoemaker, and G. Gross Habituation Deficits Induced by Metabotropic Glutamate Receptors 2/3 Receptor Blockade in Mice: Reversal by Antipsychotic Drugs J. Pharmacol. Exp. Ther., February 1, 2007; 320(2): 944 - 950. [Abstract] [Full Text] [PDF]

				M. Kadohisa and D. A. Wilson Olfactory Cortical Adaptation Facilitates Detection of Odors Against Background J Neurophysiol, March 1, 2006; 95(3): 1888 - 1896. [Abstract] [Full Text] [PDF]

				C. A. Yadon and D. A. Wilson The role of metabotropic glutamate receptors and cortical adaptation in habituation of odor-guided behavior Learn. Mem., November 1, 2005; 12(6): 601 - 605. [Abstract] [Full Text] [PDF]

				M. S. Cowen, E. Djouma, and A. J. Lawrence The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 590 - 600. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help