QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, March 9, 2005, 25(10):2547-2556; doi:10.1523/JNEUROSCI.4186-04.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Miyachi, S. Articles by Takada, M. Search for Related Content PubMed PubMed Citation Articles by Miyachi, S. Articles by Takada, M.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Organization of Multisynaptic Inputs from Prefrontal Cortex to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Rabies Virus

Shigehiro Miyachi,^1,2 Xiaofeng Lu,³ Satoshi Inoue,⁴ Takuya Iwasaki,⁵ Satoshi Koike,¹ Atsushi Nambu,⁶ and Masahiko Takada^1,2

¹Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183-8526, Japan, ²Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan, ³Department of Physiology, Juntendo University School of Medicine, Tokyo 113-8421, Japan, ⁴National Institute of Infectious Diseases, Tokyo 162-8640, Japan, ⁵Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan, and ⁶National Institute for Physiological Sciences, Okazaki 444-8585, Japan

The organization of multisynaptic projections from the prefrontal cortex to the primary motor cortex (MI) was examined in macaque monkeys by retrograde transneuronal transport of rabies virus. In the first series of experiments, the virus was injected into the MI forelimb region, and the time-dependent distribution patterns of transsynaptic labeling were analyzed in the frontal lobe with various survivals (2-4 d). Two days after the viral injection, neuronal labeling emerged in the caudal aspects of the nonprimary motor-related areas that are known to project to the MI directly. At the same time, the motor thalamus contained labeled neurons. On the third day, cortical labeling extended into the rostral motor-related areas and, also, prearcuate area 8. Moreover, a number of labeled neurons were located in the internal pallidum and the cerebellar nuclei. At the 4 d postinjection period, neuronal labeling occurred widely in prefrontal areas as well as in the putamen and the cerebellar cortex. In the second series of experiments, the viral injection was made into the MI hindlimb region, and the distribution pattern of prefrontal labeling on the fourth day was compared with that in the forelimb-injection case. The labeled neurons in each prefrontal area were much fewer in the hindlimb-injection case than in the forelimb-injection case. Whereas ventral area 46 was most densely labeled from the forelimb region, only sparse labeling from the hindlimb region was observed in this prefrontal area. The present results suggest the importance of ventral area 46 in the cognitive control of forelimb movements.

Key words: prefrontal cortex; primary motor cortex; cortical motor-related areas; somatotopy; basal ganglia; cerebellum

---

Received May 12, 2004; revised December 7, 2004; accepted December 10, 2004.

This article has been cited by other articles:

				J. Tanji and E. Hoshi Role of the Lateral Prefrontal Cortex in Executive Behavioral Control Physiol Rev, January 1, 2008; 88(1): 37 - 57. [Abstract] [Full Text] [PDF]

				P. C. J. Taylor, A. C. Nobre, and M. F. S. Rushworth Subsecond Changes in Top Down Control Exerted by Human Medial Frontal Cortex during Conflict and Action Selection: A Combined Transcranial Magnetic Stimulation Electroencephalography Study J. Neurosci., October 17, 2007; 27(42): 11343 - 11353. [Abstract] [Full Text] [PDF]

				M. SAKAGAMI and M. WATANABE Integration of Cognitive and Motivational Information in the Primate Lateral Prefrontal Cortex Ann. N.Y. Acad. Sci., May 1, 2007; 1104(1): 89 - 107. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help