 |
||||
|
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, March 16, 2005, 25(11):2992-3001; doi:10.1523/JNEUROSCI.3652-04.2005
Previous Article | Next Article
Cellular/Molecular
Developmental Switch in Synaptic Mechanisms of Hippocampal Metabotropic Glutamate Receptor-Dependent Long-Term Depression
Elena D. Nosyreva andKimberly M. Huber Center for Basic Neuroscience, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111
The presynaptic and postsynaptic properties of synapses change over the course of postnatal development. Therefore, synaptic plasticity mechanisms would be expected to adapt to these changes to facilitate alterations of synaptic strength throughout ontogeny. Here, we identified developmental changes in long-term depression (LTD) mediated by group 1 metabotropic glutamate receptors (mGluRs) and dendritic protein synthesis in hippocampal CA1 slices (mGluR-LTD). In slices prepared from adolescent rats [postnatal day 21 (P21) to P35], mGluR activation induces LTD and a long-term decrease in AMPA receptor (AMPAR) surface expression, both of which require protein synthesis. In neonatal animals (P8-P15), mGluR-LTD is independent of protein synthesis and is not associated with changes in the surface expression of AMPARs. Instead, mGluR-LTD at neonatal synapses results in large decreases in presynaptic function, measured by changes in paired-pulse facilitation and the rate of blockade by the use-dependent NMDA receptor blocker (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate. Conversely, mGluR-LTD at mature synapses results in little or no change in presynaptic function, suggesting a postsynaptic mechanism of expression. The developmental switch in the synaptic mechanisms of LTD would differentially affect synapse dynamics and perhaps information processing over the course of postnatal development.
Key words: metabotropic glutamate receptor; long-term depression; protein synthesis; AMPA receptor endocytosis; hippocampus; CA1
Received Sep 3, 2004; revised January 21, 2005; accepted February 4, 2005.
This article has been cited by other articles:
J. Strandberg, P. Wasling, and B. Gustafsson
Modulation of Low-Frequency-Induced Synaptic Depression in the Developing CA3-CA1 Hippocampal Synapses by NMDA and Metabotropic Glutamate Receptor Activation
J Neurophysiol, May 1, 2009; 101(5): 2252 - 2262.
[Abstract] [Full Text] [PDF]
D. R. Ireland and W. C. Abraham
Mechanisms of Group I mGluR-Dependent Long-Term Depression of NMDA Receptor-Mediated Transmission at Schaffer Collateral-CA1 Synapses
J Neurophysiol, March 1, 2009; 101(3): 1375 - 1385.
[Abstract] [Full Text] [PDF]
S. B. Christie, M. R. Akins, J. E. Schwob, and J. R. Fallon
The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits
J. Neurosci., February 4, 2009; 29(5): 1514 - 1524.
[Abstract] [Full Text] [PDF]
R. Corlew, D. J. Brasier, D. E. Feldman, and B. D. Philpot
Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity
Neuroscientist, December 1, 2008; 14(6): 609 - 625.
[Abstract] [PDF]
B. A. Grueter, Z. A. McElligott, A. J. Robison, G. C. Mathews, and D. G. Winder
In Vivo Metabotropic Glutamate Receptor 5 (mGluR5) Antagonism Prevents Cocaine-Induced Disruption of Postsynaptically Maintained mGluR5-Dependent Long-Term Depression
J. Neurosci., September 10, 2008; 28(37): 9261 - 9270.
[Abstract] [Full Text] [PDF]
P. R. Moult, S. A. L. Correa, G. L. Collingridge, S. M. Fitzjohn, and Z. I. Bashir
Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression
J. Physiol., May 15, 2008; 586(10): 2499 - 2510.
[Abstract] [Full Text] [PDF]
I. Bureau, G. M. G. Shepherd, and K. Svoboda
Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice
J. Neurosci., May 14, 2008; 28(20): 5178 - 5188.
[Abstract] [Full Text] [PDF]
M. D. Antion, L. Hou, H. Wong, C. A. Hoeffer, and E. Klann
mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice
Mol. Cell. Biol., May 1, 2008; 28(9): 2996 - 3007.
[Abstract] [Full Text] [PDF]
H. P. Goodkin, S. Joshi, Z. Mtchedlishvili, J. Brar, and J. Kapur
Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus
J. Neurosci., March 5, 2008; 28(10): 2527 - 2538.
[Abstract] [Full Text] [PDF]
H. E. Speed and L. E. Dobrunz
Developmental Decrease in Short-Term Facilitation at Schaffer Collateral Synapses in Hippocampus Is mGluR1 Sensitive
J Neurophysiol, February 1, 2008; 99(2): 799 - 813.
[Abstract] [Full Text] [PDF]
L. Pan and K. S. Broadie
Drosophila Fragile X Mental Retardation Protein and Metabotropic Glutamate Receptor A Convergently Regulate the Synaptic Ratio of Ionotropic Glutamate Receptor Subclasses
J. Neurosci., November 7, 2007; 27(45): 12378 - 12389.
[Abstract] [Full Text] [PDF]
A. Kumar and T. C. Foster
Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses
J Neurophysiol, November 1, 2007; 98(5): 2729 - 2736.
[Abstract] [Full Text] [PDF]
L. J. Volk, B. E. Pfeiffer, J. R. Gibson, and K. M. Huber
Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long-Term Depression That Is Affected in Fragile X Syndrome Mental Retardation
J. Neurosci., October 24, 2007; 27(43): 11624 - 11634.
[Abstract] [Full Text] [PDF]
P. A. McCoy and L. L. McMahon
Muscarinic Receptor Dependent Long-Term Depression in Rat Visual Cortex Is PKC Independent but Requires ERK1/2 Activation and Protein Synthesis
J Neurophysiol, October 1, 2007; 98(4): 1862 - 1870.
[Abstract] [Full Text] [PDF]
R. Corlew, Y. Wang, H. Ghermazien, A. Erisir, and B. D. Philpot
Developmental Switch in the Contribution of Presynaptic and Postsynaptic NMDA Receptors to Long-Term Depression
J. Neurosci., September 12, 2007; 27(37): 9835 - 9845.
[Abstract] [Full Text] [PDF]
T. Kirschstein, M. Bauer, L. Muller, C. Ruschenschmidt, M. Reitze, A. J. Becker, S. Schoch, and H. Beck
Loss of Metabotropic Glutamate Receptor-Dependent Long-Term Depression via Downregulation of mGluR5 after Status Epilepticus
J. Neurosci., July 18, 2007; 27(29): 7696 - 7704.
[Abstract] [Full Text] [PDF]
F. Chaouloff, A. Hemar, and O. Manzoni
Acute Stress Facilitates Hippocampal CA1 Metabotropic Glutamate Receptor-Dependent Long-Term Depression
J. Neurosci., July 4, 2007; 27(27): 7130 - 7135.
[Abstract] [Full Text] [PDF]
H. H. Yin, M. I. Davis, J. A. Ronesi, and D. M. Lovinger
The Role of Protein Synthesis in Striatal Long-Term Depression.
J. Neurosci., November 15, 2006; 26(46): 11811 - 11820.
[Abstract] [Full Text] [PDF]
X.-l. Zhang, Z.-y. Zhou, J. Winterer, W. Muller, and P. K. Stanton
NMDA-Dependent, But Not Group I Metabotropic Glutamate Receptor-Dependent, Long-Term Depression at Schaffer Collateral-CA1 Synapses Is Associated with Long-Term Reduction of Release from the Rapidly Recycling Presynaptic Vesicle Pool
J. Neurosci., October 4, 2006; 26(40): 10270 - 10280.
[Abstract] [Full Text] [PDF]
K. Van Keuren-Jensen and H. T. Cline
Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by homer1a induction.
J. Neurosci., July 19, 2006; 26(29): 7575 - 7580.
[Abstract] [Full Text] [PDF]
B. E. Pfeiffer and K. M. Huber
Current advances in local protein synthesis and synaptic plasticity.
J. Neurosci., July 5, 2006; 26(27): 7147 - 7150.
[Abstract] [Full Text] [PDF]
J. Qian and J. L. Noebels
Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse.
J. Neurosci., May 31, 2006; 26(22): 6089 - 6095.
[Abstract] [Full Text] [PDF]
K. J. O'Riordan, I-C. Huang, M. Pizzi, P. Spano, F. Boroni, R. Egli, P. Desai, O. Fitch, L. Malone, H. Jin Ahn, et al.
Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors.
J. Neurosci., May 3, 2006; 26(18): 4870 - 4879.
[Abstract] [Full Text] [PDF]
E. D. Nosyreva and K. M. Huber
Metabotropic Receptor-Dependent Long-Term Depression Persists in the Absence of Protein Synthesis in the Mouse Model of Fragile X Syndrome
J Neurophysiol, May 1, 2006; 95(5): 3291 - 3295.
[Abstract] [Full Text] [PDF]
K. J. Bender, C. B. Allen, V. A. Bender, and D. E. Feldman
Synaptic basis for whisker deprivation-induced synaptic depression in rat somatosensory cortex.
J. Neurosci., April 19, 2006; 26(16): 4155 - 4165.
[Abstract] [Full Text] [PDF]
V. A. Bender, K. J. Bender, D. J. Brasier, and D. E. Feldman
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
J. Neurosci., April 19, 2006; 26(16): 4166 - 4177.
[Abstract] [Full Text] [PDF]
L. J. Volk, C. A. Daly, and K. M. Huber
Differential Roles for Group 1 mGluR Subtypes in Induction and Expression of Chemically Induced Hippocampal Long-Term Depression
J Neurophysiol, April 1, 2006; 95(4): 2427 - 2438.
[Abstract] [Full Text] [PDF]
B. A. Grueter, H. B. Gosnell, C. M. Olsen, N. L. Schramm-Sapyta, T. Nekrasova, G. E. Landreth, and D. G. Winder
Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration.
J. Neurosci., March 22, 2006; 26(12): 3210 - 3219.
[Abstract] [Full Text] [PDF]
P. R. Moult, C. M. Gladding, T. M. Sanderson, S. M. Fitzjohn, Z. I. Bashir, E. Molnar, and G. L. Collingridge
Tyrosine Phosphatases Regulate AMPA Receptor Trafficking during Metabotropic Glutamate Receptor-Mediated Long-Term Depression
J. Neurosci., March 1, 2006; 26(9): 2544 - 2554.
[Abstract] [Full Text] [PDF]
P. Moretti, J. M. Levenson, F. Battaglia, R. Atkinson, R. Teague, B. Antalffy, D. Armstrong, O. Arancio, J. D. Sweatt, and H. Y. Zoghbi
Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome
J. Neurosci., January 4, 2006; 26(1): 319 - 327.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|