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The Journal of Neuroscience, April 6, 2005, 25(14):3586-3592; doi:10.1523/JNEUROSCI.0324-05.2005

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Cellular/Molecular
Continuous and Overlapping Expression Domains of Odorant Receptor Genes in the Olfactory Epithelium Determine the Dorsal/Ventral Positioning of Glomeruli in the Olfactory Bulb

Kazunari Miyamichi,^1,3 * Shou Serizawa,^2,3 * Hiroko M. Kimura,^1,3 and Hitoshi Sakano^1,3

¹Core Research for Evolutional Science and Technology and ²Precursory Research for Embryonic Science and Technology Programs of Japan Science and Technology Agency and ³Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan

In mammals, olfactory signals received by odorant receptors (ORs) in the olfactory epithelium (OE) are converted to a topographical map of activated glomeruli in the olfactory bulb (OB). It has been reported that the OE can be divided into four topographically distinct zones and that olfactory sensory neurons (OSNs) expressing a particular OR gene are randomly distributed within one zone. Here, we analyzed 80 different class II OR genes for their expression patterns in the OE by in situ hybridization. It was found that the expression area in the OE does not always fit into one of the four conventional zones. Expression areas are specific to each OR gene and are arranged in an overlapping and continuous manner in the OE. We also analyzed a spatial relationship between the OE and the OB for OSN projection. Our transgenic as well as DiI retrograde staining experiments demonstrated that the dorsal/ventral arrangement of glomeruli in the OB is correlated with the expression areas of corresponding ORs along the dorsomedial/ventrolateral axis in the OE. The present study indicates that the OR gene choice may be more restricted by the OSN location in the OE than what has been thought.

Key words: olfactory epithelium; olfactory bulb; olfactory sensory neuron; axonal projection; odorant receptor gene; positioning of glomeruli

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Received Jan 24, 2005; revised February 21, 2005; accepted February 25, 2005.

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