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The Journal of Neuroscience, April 13, 2005, 25(15):3900-3907; doi:10.1523/JNEUROSCI.0102-05.2005
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Behavioral/Systems/Cognitive
Modular Organization of Excitatory Circuits between Neurons of the Spinal Superficial Dorsal Horn (Laminae I and II)
Yan Lu andEdward R. Perl Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599
Neural circuitry of the spinal superficial dorsal horn (SDH) (laminae I and II) and its relationship to pain and other somatosensory phenomena remain poorly understood. To gain information on this issue, synaptic connections between identified SDH neurons were studied in rat spinal cord slices by simultaneous whole-cell recordings from pairs of cells. Both excitatory and inhibitory connections were noted. This report focuses on the observed excitatory linkages. Synaptic excitatory connections between SDH neurons proved highly selective and consistently were unidirectional. Two patterns repeatedly appeared (for neuron classification, see Materials and Methods) (Grudt and Perl, 2002). Lamina II central neurons, with dorsal root (DR) C-fiber input, monosynaptically excited lamina II vertical neurons with DR A
input. Lamina II outer vertical neurons with DR A
Key words: substantia gelatinosa; marginal zone; connected neurons; neural circuits; pain; dorsal horn
Received Jan 10, 2005; revised March 4, 2005; accepted March 5, 2005.
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