QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 13, 2005, 25(15):3919-3931; doi:10.1523/JNEUROSCI.0266-05.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Gerwig, M. Articles by Timmann, D. Search for Related Content PubMed PubMed Citation Articles by Gerwig, M. Articles by Timmann, D.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Timing of Conditioned Eyeblink Responses Is Impaired in Cerebellar Patients

Marcus Gerwig,¹ Karim Hajjar,¹ Albena Dimitrova,¹ Matthias Maschke,¹ Florian P. Kolb,³ Markus Frings,¹ Alfred F. Thilmann,⁴ Michael Forsting,² Hans Christoph Diener,¹ and Dagmar Timmann¹

Departments of ¹Neurology and ²Neuroradiology, University of Duisburg-Essen, D-45147 Essen, Germany, ³Department of Physiology, University of Munich, D-80336 Munich, Germany, and ⁴Department of Neurology, Fachklinik Rhein-Ruhr, D-45219 Essen, Germany

In the present study, timing of conditioned eyeblink responses (CRs) was investigated in cerebellar patients and age-matched controls using a standard delay paradigm. Findings were compared with previously published data of CR incidences in the same patient population (Gerwig et al., 2003; Timmann et al., 2005). Sixteen patients with pure cortical cerebellar degeneration (spinocerebellar ataxia type 6 and idiopathic cerebellar ataxia), 14 patients with lesions within the territory of the superior cerebellar artery, and 13 patients with infarctions within the territory of the posterior inferior cerebellar artery were included. The affected cerebellar lobules and possible involvement of cerebellar nuclei were determined by three-dimensional magnetic resonance imaging (MRI) in patients with focal lesions (n = 27). Based on a voxel-by-voxel analysis, MRI lesion data were related to eyeblink conditioning data. CR incidence was significantly reduced, and CRs occurred significantly earlier in patients with cortical cerebellar degeneration and lesions of the superior cerebellum compared with controls. Incidence and timing of CRs was not impaired in patients with lesions restricted to the posterior and inferior cerebellum. Voxel-based MRI analysis revealed that cortical areas within the anterior lobe (Larsell lobule HV) were most significantly related to timing deficits, whereas reduced CR incidences were related to more caudal parts (lobule HVI) of the superior cerebellar cortex. The present data suggest that different parts of the superior cerebellar cortex may be involved in the formation of the stimulus association and appropriate timing of conditioned eyeblink responses in humans. Extracerebellar premotoneuronal disinhibition, however, is another possible explanation for changes in CR timing.

Key words: blink reflex; eyeblink conditioning; associative learning; timing; cerebellum; human

---

Received July 9, 2004; revised February 27, 2005; accepted March 2, 2005.

This article has been cited by other articles:

				M. Kronenbuerger, M. Gerwig, B. Brol, F. Block, and D. Timmann Eyeblink conditioning is impaired in subjects with essential tremor Brain, June 1, 2007; 130(6): 1538 - 1551. [Abstract] [Full Text] [PDF]

				R. R. Kimpo and J. L. Raymond Impaired Motor Learning in the Vestibulo-Ocular Reflex in Mice with Multiple Climbing Fiber Input to Cerebellar Purkinje Cells J. Neurosci., May 23, 2007; 27(21): 5672 - 5682. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help