 |
||||
|
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, April 20, 2005, 25(16):3995-4003; doi:10.1523/JNEUROSCI.4631-04.2005
Previous Article | Next Article
Development/Plasticity/Repair
The Chemokine Stromal Cell-Derived Factor-1 Regulates the Migration of Sensory Neuron Progenitors
Abdelhak Belmadani,1 Phuong B. Tran,1 Dongjun Ren,1 Stavroula Assimacopoulos,2 Elizabeth A. Grove,2 andRichard J. Miller1 1Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, and 2Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637
Chemokines and their receptors are essential for the development and organization of the hematopoietic/lymphopoietic system and have now been shown to be expressed by different types of cells in the nervous system. In mouse embryos, we observed expression of the chemokine (CXC motif) receptor 4 (CXCR4) by neural crest cells migrating from the dorsal neural tube and in the dorsal root ganglia (DRGs). Stromal cell-derived factor-1 (SDF-1), the unique agonist for CXCR4, was expressed along the path taken by crest cells to the DRGs, suggesting that SDF-1/CXCR4 signaling is needed for their migration. CXCR4 null mice exhibited small and malformed DRGs. Delayed migration to the DRGs was suggested by ectopic cells expressing tyrosine receptor kinase A (TrkA) and TrkC, neurotrophin receptors required by DRG sensory neuron development. In vitro, the CXCR4 chemokine receptor was upregulated by migratory progenitor cells just as they exited mouse neural tube explants, and SDF-1 acted as a chemoattractant for these cells. Most CXCR4-expressing progenitors differentiated to form sensory neurons with the properties of polymodal nociceptors. Furthermore, DRGs contained a population of progenitor cells that expressed CXCR4 receptors in vitro and differentiated into neurons with a similar phenotype. Our findings indicate an important role for SDF-1/CXCR4 signaling in directing the migration of sensory neuron progenitors to the DRG and potentially in other aspects of development once the DRGs have coalesced.
Key words: CXCR4 receptors; SDF-1; neural crest; migration; sensory neurons; neurogenesis
Received June 15, 2004; revised February 23, 2005; accepted March 9, 2005.
This article has been cited by other articles:
R. J. Miller, W. Rostene, E. Apartis, G. Banisadr, K. Biber, E. D. Milligan, F. A. White, and J. Zhang
Chemokine Action in the Nervous System
J. Neurosci., November 12, 2008; 28(46): 11792 - 11795.
[Full Text] [PDF]
Y. Luo, J. Lathia, M. Mughal, and M. P. Mattson
SDF1{alpha}/CXCR4 Signaling, via ERKs and the Transcription Factor Egr1, Induces Expression of a 67-kDa Form of Glutamic Acid Decarboxylase in Embryonic Hippocampal Neurons
J. Biol. Chem., September 5, 2008; 283(36): 24789 - 24800.
[Abstract] [Full Text] [PDF]
Y. Ohshima, T. Kubo, R. Koyama, M. Ueno, M. Nakagawa, and T. Yamashita
Regulation of Axonal Elongation and Pathfinding from the Entorhinal Cortex to the Dentate Gyrus in the Hippocampus by the Chemokine Stromal Cell-Derived Factor 1{alpha}
J. Neurosci., August 13, 2008; 28(33): 8344 - 8353.
[Abstract] [Full Text] [PDF]
S. Kuriyama and R. Mayor
Molecular analysis of neural crest migration
Phil Trans R Soc B, April 12, 2008; 363(1495): 1349 - 1362.
[Abstract] [Full Text] [PDF]
A. S. Borders, M. A. Hersh, M. L. Getchell, N. van Rooijen, D. A. Cohen, A. J. Stromberg, and T. V. Getchell
Macrophage-mediated neuroprotection and neurogenesis in the olfactory epithelium
Physiol Genomics, November 14, 2007; 31(3): 531 - 543.
[Abstract] [Full Text] [PDF]
R. Shechter, Y. Ziv, and M. Schwartz
New GABAergic Interneurons Supported by Myelin-Specific T Cells Are Formed in Intact Adult Spinal Cord
Stem Cells, September 1, 2007; 25(9): 2277 - 2282.
[Abstract] [Full Text] [PDF]
H.-Y. Li, E. H. M. Say, and X.-F. Zhou
Isolation and Characterization of Neural Crest Progenitors from Adult Dorsal Root Ganglia
Stem Cells, August 1, 2007; 25(8): 2053 - 2065.
[Abstract] [Full Text] [PDF]
P. Sathyanarayana, M. P. Menon, O. Bogacheva, O. Bogachev, K. Niss, W. S. Kapelle, E. Houde, J. Fang, and D. M. Wojchowski
Erythropoietin modulation of podocalyxin and a proposed erythroblast niche
Blood, July 15, 2007; 110(2): 509 - 518.
[Abstract] [Full Text] [PDF]
N. Miyasaka, H. Knaut, and Y. Yoshihara
Cxcl12/Cxcr4 chemokine signaling is required for placode assembly and sensory axon pathfinding in the zebrafish olfactory system
Development, July 1, 2007; 134(13): 2459 - 2468.
[Abstract] [Full Text] [PDF]
R. Stumm and V. Hollt
CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain
J. Mol. Endocrinol., March 1, 2007; 38(3): 377 - 382.
[Abstract] [Full Text] [PDF]
A. Balbir, H. Lee, M. Okumura, S. Biswal, R. S. Fitzgerald, and M. Shirahata
A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice
Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L704 - L715.
[Abstract] [Full Text] [PDF]
M. F. Paredes, G. Li, O. Berger, S. C. Baraban, and S. J. Pleasure
Stromal-Derived Factor-1 (CXCL12) Regulates Laminar Position of Cajal-Retzius Cells in Normal and Dysplastic Brains.
J. Neurosci., September 13, 2006; 26(37): 9404 - 9412.
[Abstract] [Full Text] [PDF]
S. Hu, M. C.-J. Cheeran, W. S. Sheng, H. T. Ni, J. R. Lokensgard, and P. K. Peterson
Cocaine Alters Proliferation, Migration, and Differentiation of Human Fetal Brain-Derived Neural Precursor Cells
J. Pharmacol. Exp. Ther., September 1, 2006; 318(3): 1280 - 1286.
[Abstract] [Full Text] [PDF]
G. A. Schwarting, T. R. Henion, J. D. Nugent, B. Caplan, and S. Tobet
Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain.
J. Neurosci., June 21, 2006; 26(25): 6834 - 6840.
[Abstract] [Full Text] [PDF]
A. Belmadani, P. B. Tran, D. Ren, and R. J. Miller
Chemokines regulate the migration of neural progenitors to sites of neuroinflammation.
J. Neurosci., March 22, 2006; 26(12): 3182 - 3191.
[Abstract] [Full Text] [PDF]
S. A. Tobet and G. A. Schwarting
Minireview: Recent Progress in Gonadotropin-Releasing Hormone Neuronal Migration
Endocrinology, March 1, 2006; 147(3): 1159 - 1165.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|