QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 27, 2005, 25(17):4252-4259; doi:10.1523/JNEUROSCI.4721-04.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Mutoh, H. Articles by Knöpfel, T. Search for Related Content PubMed PubMed Citation Articles by Mutoh, H. Articles by Knöpfel, T. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL GLYCINE TETRODOTOXIN

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Long-Term Depression at Olfactory Nerve Synapses

Hiroki Mutoh, Qi Yuan, and Thomas Knöpfel

Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-0198, Japan

The synapses formed by the olfactory nerve (ON) convey sensory information to olfactory glomeruli, the first stage of central odor processing. Morphological and behavioral studies suggest that glomerular odor processing is plastic in neonate rodents. However, long-term synaptic plasticity, a cellular correlate of functional and structural plasticity, has not yet been demonstrated in this system. Here, we report that ONmitral cell (MC) synapses of 5- to 8-d-old mice express long-term depression (LTD) after brief low-frequency ON stimulation. Pharmacological techniques and imaging of presynaptic calcium signals demonstrate that ON-MC LTD is expressed presynaptically and requires the activation of metabotropic glutamate receptors but does not require fast synaptic transmission. LTD at the ON MC synapse is potentially relevant for the establishment, maintenance, and experience-dependent refinement of odor maps in the olfactory bulb.

Key words: calcium (Ca); imaging; olfactory; patch clamp; metabotropic glutamate receptor; plasticity; LTD

---

Received Nov 18, 2004; revised March 17, 2005; accepted March 21, 2005.

This article has been cited by other articles:

				Q. Yuan Theta bursts in the olfactory nerve paired with {beta}-adrenoceptor activation induce calcium elevation in mitral cells: A mechanism for odor preference learning in the neonate rat Learn. Mem., October 26, 2009; 16(11): 676 - 681. [Abstract] [Full Text] [PDF]

				M. S. Grubb, A. Nissant, K. Murray, and P.-M. Lledo Functional Maturation of the First Synapse in Olfaction: Development and Adult Neurogenesis J. Neurosci., March 12, 2008; 28(11): 2919 - 2932. [Abstract] [Full Text] [PDF]

				W. J. Tyler, G. C. Petzold, S. K. Pal, and V. N. Murthy Experience-Dependent Modification of Primary Sensory Synapses in the Mammalian Olfactory Bulb J. Neurosci., August 29, 2007; 27(35): 9427 - 9438. [Abstract] [Full Text] [PDF]

				Q. Yuan and T. Knopfel Olfactory Nerve Stimulation-Evoked mGluR1 Slow Potentials, Oscillations, and Calcium Signaling in Mouse Olfactory Bulb Mitral Cells J Neurophysiol, May 1, 2006; 95(5): 3097 - 3104. [Abstract] [Full Text] [PDF]

				Q. Yuan and T. Knopfel Olfactory Nerve Stimulation-Induced Calcium Signaling in the Mitral Cell Distal Dendritic Tuft J Neurophysiol, April 1, 2006; 95(4): 2417 - 2426. [Abstract] [Full Text] [PDF]

				M. Ennis, M. Zhu, T. Heinbockel, and A. Hayar Olfactory Nerve-Evoked, Metabotropic Glutamate Receptor-Mediated Synaptic Responses in Rat Olfactory Bulb Mitral Cells J Neurophysiol, April 1, 2006; 95(4): 2233 - 2241. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help