WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Advertisement
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, April 27, 2005, 25(17):4370-4374; doi:10.1523/JNEUROSCI.4437-04.2005

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Riba, J.
Right arrow Articles by Barbanoj, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Riba, J.
Right arrow Articles by Barbanoj, M. J.

 Previous Article  |  Next Article 

BRIEF COMMUNICATION
Noradrenergic Stimulation Enhances Human Action Monitoring

Jordi Riba,1,3 Antoni Rodríguez-Fornells,2 Adelaida Morte,1 Thomas F. Münte,3 and Manel J. Barbanoj1

1Centre d'Investigació de Medicaments, Institut de Recerca, Servei de Farmacologia Clínica, Hospital de la Santa Creu i Sant Pau, Departament de Farmacologia i Terapèutica, Universitat Autònoma de Barcelona, 08025 Barcelona, Spain, 2Faculty of Psychology, University of Barcelona and Institució Catalana de Recerca i Estudis Avançats, 08035 Barcelona, Spain, and 3Department of Neuropsychology, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany

Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by event-related brain potentials, was examined. After the administration of a placebo or the selective {alpha}2-adrenoceptor antagonist yohimbine, which stimulates firing in the locus ceruleus and noradrenaline release, electroencephalograpic recordings were obtained from healthy volunteers performing a letter flanker task. Yohimbine led to an increase in the amplitude of the error-related negativity in conjunction with a significant reduction of action errors. Reaction times were unchanged, and the drug did not modify the N2 in congruent versus incongruent trials, a measure of preresponse conflict, or posterror adjustments as measured by posterror slowing of reaction time. The present findings suggest that the locus ceruleus-noradrenaline system exerts a rather specific effect on human action monitoring.

Key words: action monitoring; prefrontal cortex; ERN; yohimbine; noradrenaline; human

Received Oct 27, 2004; revised February 25, 2005; accepted March 7, 2005.




This article has been cited by other articles:


Home page
 J. Cogn. Neurosci.Home page
J. Marco-Pallares, E. Camara, T. F. Munte, and A. Rodriguez-Fornells
Neural Mechanisms Underlying Adaptive Actions after Slips
J. Cogn. Neurosci., September 1, 2008; 20(9): 1595 - 1610.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Michelet, B. Bioulac, D. Guehl, L. Escola, and P. Burbaud
Impact of Commitment on Performance Evaluation in the Rostral Cingulate Motor Area
J. Neurosci., July 11, 2007; 27(28): 7482 - 7489.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-