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The Journal of Neuroscience, May 4, 2005, 25(18):4616-4625; doi:10.1523/JNEUROSCI.0455-05.2005
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Behavioral/Systems/Cognitive
Multisensory Space Representations in the Macaque Ventral Intraparietal Area
Anja Schlack,1 Susanne J. Sterbing-D'Angelo,1 Klaus Hartung,2 Klaus-Peter Hoffmann,1 andFrank Bremmer1 1Department of Zoology and Neurobiology and 2Institute for Communication Acoustics, Ruhr-University Bochum, 44780 Bochum, Germany
Animals can use different sensory signals to localize objects in the environment. Depending on the situation, the brain either integrates information from multiple sensory sources or it chooses the modality conveying the most reliable information to direct behavior. This suggests that somehow, the brain has access to a modality-invariant representation of external space. Accordingly, neural structures encoding signals from more than one sensory modality are best suited for spatial information processing. In primates, the posterior parietal cortex (PPC) is a key structure for spatial representations. One substructure within human and macaque PPC is the ventral intraparietal area (VIP), known to represent visual, vestibular, and tactile signals. In the present study, we show for the first time that macaque area VIP neurons also respond to auditory stimulation. Interestingly, the strength of the responses to the acoustic stimuli greatly depended on the spatial location of the stimuli [i.e., most of the auditory responsive neurons had surprisingly small spatially restricted auditory receptive fields (RFs)].
Given this finding, we compared the auditory RF locations with the respective visual RF locations of individual area VIP neurons. In the vast majority of neurons, the auditory and visual RFs largely overlapped. Additionally, neurons with well aligned visual and auditory receptive fields tended to encode multisensory space in a common reference frame. This suggests that area VIP constitutes a part of a neuronal circuit involved in the computation of a modality-invariant representation of external space.
Key words: multisensory; space representation; area VIP; auditory; visual; reference frames
Received Oct 19, 2004; revised March 21, 2005; accepted March 27, 2005.
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