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The Journal of Neuroscience, January 12, 2005, 25(2):514-523; doi:10.1523/JNEUROSCI.3369-04.2005

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Behavioral/Systems/Cognitive
Distinct Properties of Stimulus-Evoked Bursts in the Lateral Geniculate Nucleus

Henry J. Alitto,¹ Theodore G. Weyand,² and W. Martin Usrey¹

¹Center for Neuroscience, University of California, Davis, California 95616, and ²Department of Cell Biology and Anatomy, Louisiana State University Medical Center, New Orleans, Louisiana 70112

Neurons in the lateral geniculate nucleus (LGN) of the thalamus produce spikes that can be classified as burst spikes and tonic spikes. Although burst spikes are generally associated with states of sleep and drowsiness, bursts may also play an important role in sensory processing. This study explores the stimulus properties that evoke burst and tonic spikes and examines the reliability of LGN neurons to produce visually driven bursts. Using reverse-correlation techniques, we show that the receptive fields of burst spikes are similar to, but significantly different from, the receptive fields of tonic spikes. Compared with tonic spikes, burst spikes (1) occur with a shorter latency between stimulus and response, (2) have a greater dependence on stimuli with transitions from suppressive to preferred states, and (3) prefer stimuli that provide increased drive to the receptive field center and even greater increased drive to the receptive field surround. These differences are not attributable to the long interspike interval that precedes burst spikes, because tonic spikes with similar preceding interspike intervals also differ from burst spikes in both the spatial and temporal domains. Finally, measures of reliability are significantly greater for burst spikes than for tonic spikes with similar preceding interspike intervals. These results demonstrate that thalamic bursts contribute to sensory processing and can reliably provide the cortex with information that is similar to, but distinct from, that of tonic spikes.

Key words: thalamus; vision; visual; bursts; LGN; cat; coding

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Received Aug 17, 2004; revised November 15, 2004; accepted November 20, 2004.

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