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The Journal of Neuroscience, June 8, 2005, 25(23):5475-5480; doi:10.1523/JNEUROSCI.0936-05.2005

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BRIEF COMMUNICATION
Cortical Sites Critical for Speech Discrimination in Normal and Impaired Listeners

Dana F. Boatman¹ and Diana L. Miglioretti^2,3

¹Departments of Neurology and Otolaryngology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, ²Center for Health Studies, Group Health Cooperative, Seattle, Washington 98101, and ³Department of Biostatistics, University of Washington, Seattle, Washington 98195

We used statistical modeling to investigate variability in the cortical auditory representations of 24 normal-hearing epilepsy patients undergoing electrocortical stimulation mapping (ESM). Patients were identified as normal or impaired listeners based on recognition accuracy for acoustically filtered words used to simulate everyday listening conditions. The experimental ESM task was a binary (same-different) auditory syllable discrimination paradigm that both listener groups performed accurately at baseline. Template mixture modeling of speech discrimination deficits during ESM showed larger and more variable cortical distributions for impaired listeners than normal listeners, despite comparable behavioral performances. These results demonstrate that individual differences in speech recognition abilities are reflected in the underlying cortical representations.

Key words: statistical modeling; auditory cortex; speech recognition; epilepsy; brain mapping; superior temporal gyrus

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Received Nov 12, 2004; revised April 22, 2005; accepted April 22, 2005.

This article has been cited by other articles:

				J. Obleser, J. Zimmermann, J. Van Meter, and J. P. Rauschecker Multiple Stages of Auditory Speech Perception Reflected in Event-Related fMRI Cereb Cortex, October 1, 2007; 17(10): 2251 - 2257. [Abstract] [Full Text] [PDF]

				J. Obleser, S. K. Scott, and C. Eulitz Now You Hear It, Now You Don't: Transient Traces of Consonants and their Nonspeech Analogues in the Human Brain Cereb Cortex, August 1, 2006; 16(8): 1069 - 1076. [Abstract] [Full Text] [PDF]

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