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The Journal of Neuroscience, July 20, 2005, 25(29):6921-6928; doi:10.1523/JNEUROSCI.1555-05.2005

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Development/Plasticity/Repair
Altered Map of Visual Space in the Superior Colliculus of Mice Lacking Early Retinal Waves

Thomas D. Mrsic-Flogel,¹ Sonja B. Hofer,¹ Claire Creutzfeldt,¹ Isabelle Cloëz-Tayarani,² Jean-Pierre Changeux,² Tobias Bonhoeffer,¹ and Mark Hübener¹

¹Max-Planck-Institut für Neurobiologie, D-82152 Martinsried, Germany, and ²Unité de Recherche Associée, Centre National de la Recherche Scientifique, D2182 Récepteurs et Cognition, Institut Pasteur, 75724 Paris Cedex 15, France

During the development of the mammalian retinocollicular projection, a coarse retinotopic map is set up by the graded distribution of axon guidance molecules. Subsequent refinement of the initially diffuse projection has been shown to depend on the spatially correlated firing of retinal ganglion cells. In this scheme, the abolition of patterned retinal activity is not expected to influence overall retinotopic organization, but this has not been investigated. We used optical imaging of intrinsic signals to visualize the complete retinotopic map in the superior colliculus (SC) of mice lacking early retinal waves, caused by the deletion of the 2 subunit of the nicotinic acetylcholine receptor. As expected from previous anatomical studies in the SC of 2^-/- mice, regions activated by individual visual stimuli were much larger and had less sharp borders than those in wild-type mice. Importantly, however, we also found systematic distortions of the entire retinotopic map: the map of visual space was expanded anteriorly and compressed posteriorly. Thus, patterned neuronal activity in the early retina has a substantial influence on the coarse retinotopic organization of the SC.

Key words: superior colliculus; retinal waves; retinotopic map; activity-dependent refinement; intrinsic signal imaging; 2 subunit of nicotinic acetylcholine receptor

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Received April 20, 2005; revised June 11, 2005; accepted June 16, 2005.

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