QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, July 27, 2005, 25(30):6997-7003; doi:10.1523/JNEUROSCI.1435-05.2005

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (51) Citing Articles via Google Scholar Google Scholar Articles by Kohwi, M. Articles by Alvarez-Buylla, A. Search for Related Content PubMed PubMed Citation Articles by Kohwi, M. Articles by Alvarez-Buylla, A.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Pax6 Is Required for Making Specific Subpopulations of Granule and Periglomerular Neurons in the Olfactory Bulb

Minoree Kohwi,¹ Noriko Osumi,³ John L. R. Rubenstein,² and Arturo Alvarez-Buylla¹

¹Department of Neurological Surgery and Program in Developmental and Stem Cell Biology and ²Center for Neurobiology and Psychiatry, University of California, San Francisco, San Francisco, California 94143, and ³Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, Sendai 980-8575, Japan

The subventricular zone (SVZ) produces different subclasses of olfactory bulb (OB) interneurons throughout life. Little is known about the molecular mechanisms controlling the production of different types of interneurons. Here we show that most proliferating adult SVZ progenitors express the transcription factor Pax6, but only a small subpopulation of migrating neuroblasts and new OB interneurons derived from these progenitors retains Pax6 expression. To elucidate the cell-autonomous role of Pax6 in OB neurogenesis, we transplanted green fluorescent protein-expressing embryonic forebrain progenitors of the dorsal lateral ganglionic eminence from Pax6 mutant Small Eye (Pax6^Sey/Sey) mice into the SVZ of adult wild-type mice. Pax6^Sey/Sey progenitors produce neuroblasts capable of migrating into the OB but fail to generate dopaminergic periglomerular and superficial granule cells. Interestingly, superficial granule neurons also express mRNA for tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. Our data show that SVZ neuroblasts are heterogeneous and that Pax6 is required in a cell-autonomous manner for the production of cells in the dopaminergic lineage.

Key words: adult neurogenesis; olfactory bulb; dopaminergic periglomerular cells; interneurons; Sey; mouse

---

Received April 12, 2005; revised June 7, 2005; accepted June 9, 2005.

This article has been cited by other articles:

				A. de Chevigny, O. Cooper, A. Vinuela, C. Reske-Nielsen, D. C. Lagace, A. J. Eisch, and O. Isacson Fate Mapping and Lineage Analyses Demonstrate the Production of a Large Number of Striatal Neuroblasts After Transforming Growth Factor {alpha} and Noggin Striatal Infusions into the Dopamine-Depleted Striatum Stem Cells, September 1, 2008; 26(9): 2349 - 2360. [Abstract] [Full Text] [PDF]

				R. S.E. Carney, L. A. Cocas, T. Hirata, K. Mansfield, and J. G. Corbin Differential Regulation of Telencephalic Pallial-Subpallial Boundary Patterning by Pax6 and Gsh2 Cereb Cortex, August 12, 2008; (2008) bhn123v1. [Abstract] [Full Text] [PDF]

				S. J. Harrison, R. Nishinakamura, and A. P. Monaghan Sall1 Regulates Mitral Cell Development and Olfactory Nerve Extension in the Developing Olfactory Bulb Cereb Cortex, July 1, 2008; 18(7): 1604 - 1617. [Abstract] [Full Text] [PDF]

				N. Osumi, H. Shinohara, K. Numayama-Tsuruta, and M. Maekawa Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator Stem Cells, July 1, 2008; 26(7): 1663 - 1672. [Abstract] [Full Text] [PDF]

				M. S. Brill, M. Snapyan, H. Wohlfrom, J. Ninkovic, M. Jawerka, G. S. Mastick, R. Ashery-Padan, A. Saghatelyan, B. Berninger, and M. Gotz A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb J. Neurosci., June 18, 2008; 28(25): 6439 - 6452. [Abstract] [Full Text] [PDF]

				J. Jiao and D. F. Chen Induction of Neurogenesis in Nonconventional Neurogenic Regions of the Adult Central Nervous System by Niche Astrocyte-Produced Signals Stem Cells, May 1, 2008; 26(5): 1221 - 1230. [Abstract] [Full Text] [PDF]

				K. Sakurai and N. Osumi The Neurogenesis-Controlling Factor, Pax6, Inhibits Proliferation and Promotes Maturation in Murine Astrocytes J. Neurosci., April 30, 2008; 28(18): 4604 - 4612. [Abstract] [Full Text] [PDF]

				R. E. Russo, C. Reali, M. Radmilovich, A. Fernandez, and O. Trujillo-Cenoz Connexin 43 Delimits Functional Domains of Neurogenic Precursors in the Spinal Cord J. Neurosci., March 26, 2008; 28(13): 3298 - 3309. [Abstract] [Full Text] [PDF]

				D. Colak, T. Mori, M. S. Brill, A. Pfeifer, S. Falk, C. Deng, R. Monteiro, C. Mummery, L. Sommer, and M. Gotz Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells J. Neurosci., January 9, 2008; 28(2): 434 - 446. [Abstract] [Full Text] [PDF]

				J. Malaterre, T. Mantamadiotis, S. Dworkin, S. Lightowler, Q. Yang, M. I. Ransome, A. M. Turnley, N. R. Nichols, N. R. Emambokus, J. Frampton, et al. c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain Stem Cells, January 1, 2008; 26(1): 173 - 181. [Abstract] [Full Text] [PDF]

				W. R. Kim, Y. Kim, B. Eun, O.-h. Park, H. Kim, K. Kim, C.-H. Park, S. Vinsant, R. W. Oppenheim, and W. Sun Impaired Migration in the Rostral Migratory Stream But Spared Olfactory Function after the Elimination of Programmed Cell Death in Bax Knock-Out Mice J. Neurosci., December 26, 2007; 27(52): 14392 - 14403. [Abstract] [Full Text] [PDF]

				E. J. Kim, C. T. Leung, R. R. Reed, and J. E. Johnson In Vivo Analysis of Ascl1 Defined Progenitors Reveals Distinct Developmental Dynamics during Adult Neurogenesis and Gliogenesis J. Neurosci., November 21, 2007; 27(47): 12764 - 12774. [Abstract] [Full Text] [PDF]

				M. C. Whitman and C. A. Greer Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits J. Neurosci., September 12, 2007; 27(37): 9951 - 9961. [Abstract] [Full Text] [PDF]

				K. M. Young, M. Fogarty, N. Kessaris, and W. D. Richardson Subventricular Zone Stem Cells Are Heterogeneous with Respect to Their Embryonic Origins and Neurogenic Fates in the Adult Olfactory Bulb J. Neurosci., August 1, 2007; 27(31): 8286 - 8296. [Abstract] [Full Text] [PDF]

				F. T. Merkle, Z. Mirzadeh, and A. Alvarez-Buylla Mosaic Organization of Neural Stem Cells in the Adult Brain Science, July 20, 2007; 317(5836): 381 - 384. [Abstract] [Full Text] [PDF]

				M. Kohwi, M. A. Petryniak, J. E. Long, M. Ekker, K. Obata, Y. Yanagawa, J. L. R. Rubenstein, and A. Alvarez-Buylla A Subpopulation of Olfactory Bulb GABAergic Interneurons Is Derived from Emx1- and Dlx5/6-Expressing Progenitors J. Neurosci., June 27, 2007; 27(26): 6878 - 6891. [Abstract] [Full Text] [PDF]

				M. Schmidt The Olfactory Pathway of Decapod Crustaceans--An Invertebrate Model for Life-Long Neurogenesis Chem Senses, May 1, 2007; 32(4): 365 - 384. [Abstract] [Full Text] [PDF]

				G. Gheusi and P.-M. Lledo Control of Early Events in Olfactory Processing by Adult Neurogenesis Chem Senses, May 1, 2007; 32(4): 397 - 409. [Abstract] [Full Text] [PDF]

				R. E. Ventura and J. E. Goldman Dorsal Radial Glia Generate Olfactory Bulb Interneurons in the Postnatal Murine Brain J. Neurosci., April 18, 2007; 27(16): 4297 - 4302. [Abstract] [Full Text] [PDF]

				J. E. Long, S. Garel, M. Alvarez-Dolado, K. Yoshikawa, N. Osumi, A. Alvarez-Buylla, and J. L. R. Rubenstein Dlx-Dependent and -Independent Regulation of Olfactory Bulb Interneuron Differentiation J. Neurosci., March 21, 2007; 27(12): 3230 - 3243. [Abstract] [Full Text] [PDF]

				M. A. Curtis, M. Kam, U. Nannmark, M. F. Anderson, M. Z. Axell, C. Wikkelso, S. Holtas, W. M. C. van Roon-Mom, T. Bjork-Eriksson, C. Nordborg, et al. Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension Science, March 2, 2007; 315(5816): 1243 - 1249. [Abstract] [Full Text] [PDF]

				S. De Marchis, S. Bovetti, B. Carletti, Y.-C. Hsieh, D. Garzotto, P. Peretto, A. Fasolo, A. C. Puche, and F. Rossi Generation of Distinct Types of Periglomerular Olfactory Bulb Interneurons during Development and in Adult Mice: Implication for Intrinsic Properties of the Subventricular Zone Progenitor Population J. Neurosci., January 17, 2007; 27(3): 657 - 664. [Abstract] [Full Text] [PDF]

				E. Vergano-Vera, M. J. Yusta-Boyo, F. de Castro, A. Bernad, F. de Pablo, and C. Vicario-Abejon Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells Development, November 1, 2006; 133(21): 4367 - 4379. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help