QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 10, 2005, 25(32):7393-7400; doi:10.1523/JNEUROSCI.0910-05.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (18) Citing Articles via Google Scholar Google Scholar Articles by Korz, V. Articles by Frey, J. U. Search for Related Content PubMed PubMed Citation Articles by Korz, V. Articles by Frey, J. U.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Bidirectional Modulation of Hippocampal Long-Term Potentiation under Stress and No-Stress Conditions in Basolateral Amygdala-Lesioned and Intact Rats

Volker Korz and Julietta U. Frey

Department of Neurophysiology, Leibniz-Institute for Neurobiology, D-39118 Magdeburg, Germany

Hippocampal long-term potentiation (LTP) is widely considered as a cellular model for learning and memory formation. We have shown previously that protein synthesis-independent, early dentate gyrus (DG) LTP, lasting 4-5 h, can be transformed into a late-LTP with a duration of 24 h by a brief acute swim stress experience (high-stress condition). This reinforcement requires the activation of mineralocorticoid receptors and protein synthesis. The basolateral amygdala (BLA) is known to modulate glucocorticoid effects on the consolidation of spatial/contextual memory via a -adrenergic mechanism. Interestingly, hippocampal DG-LTP can also be indirectly modulated by -adrenergic and cholinergic/muscarinergic processes. Here, we show that the reinforcement of early-DG-LTP under high-stress conditions depends on the processing of novel spatial/contextual information. Furthermore, this reinforcement was blocked in BLA-lesioned animals compared with sham-operated and intact controls; however, it was not dependent on -adrenergic or cholinergic/muscarinergic receptor activation. In contrast, under low-stress conditions, the induction of late-LTP in BLA-lesioned animals is facilitated, and this facilitation, again, was dependent on -adrenergic activation. The data suggest that DG-LTP maintenance can be influenced by the BLA through different mechanisms: a short-lasting corticosterone-dependent and -adrenergic-independent mechanism and a long-lasting mechanism that facilitated hippocampal -adrenergic mechanisms.

Key words: basolateral amygdala; early-LTP; late-LTP; locus ceruleus; memory; stress

---

Received March 8, 2005; revised June 28, 2005; accepted June 28, 2005.

This article has been cited by other articles:

				A. Kemp and D. Manahan-Vaughan {beta}-Adrenoreceptors Comprise a Critical Element in Learning-Facilitated Long-Term Plasticity Cereb Cortex, June 1, 2008; 18(6): 1326 - 1334. [Abstract] [Full Text] [PDF]

				J. Waddell, D. A. Bangasser, and T. J. Shors The Basolateral Nucleus of the Amygdala Is Necessary to Induce the Opposing Effects of Stressful Experience on Learning in Males and Females J. Neurosci., May 14, 2008; 28(20): 5290 - 5294. [Abstract] [Full Text] [PDF]

				V. Korz and J. U. Frey Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval Learn. Mem., March 8, 2007; 14(3): 160 - 166. [Abstract] [Full Text] [PDF]

				C. M. O'Carroll, S. J. Martin, J. Sandin, B. Frenguelli, and R. G.M. Morris Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory Learn. Mem., November 1, 2006; 13(6): 760 - 769. [Abstract] [Full Text] [PDF]

				S. Moriceau, D. A. Wilson, S. Levine, and R. M. Sullivan Dual circuitry for odor-shock conditioning during infancy: corticosterone switches between fear and attraction via amygdala. J. Neurosci., June 21, 2006; 26(25): 6737 - 6748. [Abstract] [Full Text] [PDF]

				B. Roozendaal, S. Okuda, E. A. Van der Zee, and J. L. McGaugh Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala PNAS, April 25, 2006; 103(17): 6741 - 6746. [Abstract] [Full Text] [PDF]

				T. Ahmed, J. U. Frey, and V. Korz Long-Term Effects of Brief Acute Stress on Cellular Signaling and Hippocampal LTP J. Neurosci., April 12, 2006; 26(15): 3951 - 3958. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help