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The Journal of Neuroscience, August 17, 2005, 25(33):7648-7659; doi:10.1523/JNEUROSCI.1990-05.2005

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Behavioral/Systems/Cognitive
Optical Imaging of SI Topography in Anesthetized and Awake Squirrel Monkeys

Li Min Chen, Robert Mark Friedman, and Anna Wang Roe

Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203

Orderly topographic maps in the primary somatosensory cortex (SI) serve as an anchor for our understanding of somatosensory cortical organization. However, this view is mostly based on data collected in the anesthetized animal. Less is known about these topographies in the awake primate. Even less is known about the relative activations of different subdivisions of SI (areas 3a, 3b, 1, and 2). Toward the goal of understanding the functional activation of SI, we conducted intrinsic signal optical imaging of areas 3b and 1 in awake squirrel monkeys. Monkeys were imaged repeatedly for a period of >2 years in awake and anesthetized states in response to vibrotactile and electrocutaneous stimuli presented to individual fingerpads. During this period, we found stable somatotopic maps in both the anesthetized and awake states, consistent with electrophysiologically recorded maps in areas 3b and 1 in the anesthetized state. In the awake animal, signal sizes were larger, but variability was greater, leading to decreased signal-to-noise ratios. Topographic activations were larger (in both area and amplitude) in the awake animal, suggesting either a less precise topography and/or more complex integration. This brings into question the role of a precise topographic map during behavior. In addition, whereas in the anesthetized animal strongest imaging signals were obtained from area 3b, in the awake animal, area 1 activation dominated over that in area 3b. Differences in relative dominance of area 3b versus area 1 suggest that inter-areal interactions in the alert animal differ substantially from that in the anesthetized animal.

Key words: optical imaging; awake; primate; somatosensory cortex; anesthesia; topography

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Received Jan 11, 2005; revised July 7, 2005; accepted July 8, 2005.

This article has been cited by other articles:

				R. M. Friedman, L. M. Chen, and A. W. Roe Responses of Areas 3b and 1 in Anesthetized Squirrel Monkeys to Single- and Dual-Site Stimulation of the Digits J Neurophysiol, December 1, 2008; 100(6): 3185 - 3196. [Abstract] [Full Text] [PDF]

				M. J. Rojas, J. A. Navas, and D. M. Rector Evoked response potential markers for anesthetic and behavioral states Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R189 - R196. [Abstract] [Full Text] [PDF]

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