 |
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, September 21, 2005, 25(38):8680-8685; doi:10.1523/JNEUROSCI.1731-05.2005
Previous Article | Next Article
BRIEF COMMUNICATION
Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice
Henriette van Praag, Tiffany Shubert, Chunmei Zhao, andFred H. Gage Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
Aging causes changes in the hippocampus that may lead to cognitive decline in older adults. In young animals, exercise increases hippocampal neurogenesis and improves learning. We investigated whether voluntary wheel running would benefit mice that were sedentary until 19 months of age. Specifically, young and aged mice were housed with or without a running wheel and injected with bromodeoxyuridine or retrovirus to label newborn cells. After 1 month, learning was tested in the Morris water maze. Aged runners showed faster acquisition and better retention of the maze than age-matched controls. The decline in neurogenesis in aged mice was reversed to 50% of young control levels by running. Moreover, fine morphology of new neurons did not differ between young and aged runners, indicating that the initial maturation of newborn neurons was not affected by aging. Thus, voluntary exercise ameliorates some of the deleterious morphological and behavioral consequences of aging.
Key words: exercise; neurogenesis; learning; aging; angiogenesis; spines
Received May 1, 2005; revised July 18, 2005; accepted August 9, 2005.
This article has been cited by other articles:
M. Koehl, P. Meerlo, D. Gonzales, A. Rontal, F. W. Turek, and D. N. Abrous
Exercise-induced promotion of hippocampal cell proliferation requires {beta}-endorphin
FASEB J, July 1, 2008; 22(7): 2253 - 2262.
[Abstract] [Full Text] [PDF]
J.-W. Wang, D. J. David, J. E. Monckton, F. Battaglia, and R. Hen
Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells
J. Neurosci., February 6, 2008; 28(6): 1374 - 1384.
[Abstract] [Full Text] [PDF]
J. A. Kleim and T. A. Jones
Principles of Experience-Dependent Neural Plasticity: Implications for Rehabilitation After Brain Damage
J Speech Lang Hear Res, February 1, 2008; 51(1): S225 - S239.
[Abstract] [Full Text] [PDF]
B. S. Peterson, H. A. Choi, X. Hao, J. A. Amat, H. Zhu, R. Whiteman, J. Liu, D. Xu, and R. Bansal
Morphologic Features of the Amygdala and Hippocampus in Children and Adults With Tourette Syndrome
Arch Gen Psychiatry, November 1, 2007; 64(11): 1281 - 1291.
[Abstract] [Full Text] [PDF]
B. Leuner, Y. Kozorovitskiy, C. G. Gross, and E. Gould
Diminished adult neurogenesis in the marmoset brain precedes old age
PNAS, October 23, 2007; 104(43): 17169 - 17173.
[Abstract] [Full Text] [PDF]
E. HEAD
Combining an Antioxidant-Fortified Diet with Behavioral Enrichment Leads to Cognitive Improvement and Reduced Brain Pathology in Aging Canines: Strategies for Healthy Aging
Ann. N.Y. Acad. Sci., October 1, 2007; 1114(1): 398 - 406.
[Abstract] [Full Text] [PDF]
F. Wurm, S. Keiner, A. Kunze, O. W. Witte, and C. Redecker
Effects of Skilled Forelimb Training on Hippocampal Neurogenesis and Spatial Learning After Focal Cortical Infarcts in the Adult Rat Brain
Stroke, October 1, 2007; 38(10): 2833 - 2840.
[Abstract] [Full Text] [PDF]
B. Hattiangady, B. Shuai, J. Cai, T. Coksaygan, M. S. Rao, and A. K. Shetty
Increased Dentate Neurogenesis After Grafting of Glial Restricted Progenitors or Neural Stem Cells in the Aging Hippocampus
Stem Cells, August 1, 2007; 25(8): 2104 - 2117.
[Abstract] [Full Text] [PDF]
B. S. McEwen
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
Physiol Rev, July 1, 2007; 87(3): 873 - 904.
[Abstract] [Full Text] [PDF]
H. van Praag, M. J. Lucero, G. W. Yeo, K. Stecker, N. Heivand, C. Zhao, E. Yip, M. Afanador, H. Schroeter, J. Hammerstone, et al.
Plant-Derived Flavanol (-)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
J. Neurosci., May 30, 2007; 27(22): 5869 - 5878.
[Abstract] [Full Text] [PDF]
A. C. Pereira, D. E. Huddleston, A. M. Brickman, A. A. Sosunov, R. Hen, G. M. McKhann, R. Sloan, F. H. Gage, T. R. Brown, and S. A. Small
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
PNAS, March 27, 2007; 104(13): 5638 - 5643.
[Abstract] [Full Text] [PDF]
L. M. Billings, K. N. Green, J. L. McGaugh, and F. M. LaFerla
Learning Decreases A{beta}*56 and Tau Pathology and Ameliorates Behavioral Decline in 3xTg-AD Mice
J. Neurosci., January 24, 2007; 27(4): 751 - 761.
[Abstract] [Full Text] [PDF]
A. F. Kramer, K. I. Erickson, and S. J. Colcombe
Exercise, cognition, and the aging brain
J Appl Physiol, October 1, 2006; 101(4): 1237 - 1242.
[Abstract] [Full Text] [PDF]
K. J. Plessen, R. Bansal, H. Zhu, R. Whiteman, J. Amat, G. A. Quackenbush, L. Martin, K. Durkin, C. Blair, J. Royal, et al.
Hippocampus and Amygdala Morphology in Attention-Deficit/Hyperactivity Disorder.
Arch Gen Psychiatry, July 1, 2006; 63(7): 795 - 807.
[Abstract] [Full Text] [PDF]
M. S. Buckwalter, M. Yamane, B. S. Coleman, B. K. Ormerod, J. T. Chin, T. Palmer, and T. Wyss-Coray
Chronically Increased Transforming Growth Factor-{beta}1 Strongly Inhibits Hippocampal Neurogenesis in Aged Mice
Am. J. Pathol., July 1, 2006; 169(1): 154 - 164.
[Abstract] [Full Text] [PDF]
S. Studenski, M. C. Carlson, H. Fillit, W. T. Greenough, A. Kramer, and G. W. Rebok
From Bedside to Bench: Does Mental and Physical Activity Promote Cognitive Vitality in Late Life?
Sci. Aging Knowl. Environ., June 28, 2006; 2006(10): pe21 - pe21.
[Abstract] [Full Text]
Y.-Y. Huang and E. R. Kandel
Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampus.
Learn. Mem., May 1, 2006; 13(3): 298 - 306.
[Abstract] [Full Text] [PDF]
C. Zhao, E. M. Teng, R. G. Summers Jr, G.-l. Ming, and F. H. Gage
Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus
J. Neurosci., January 4, 2006; 26(1): 3 - 11.
[Abstract] [Full Text] [PDF]
A. R. La Spada
Huntington's disease and neurogenesis: FGF-2 to the rescue?
PNAS, December 13, 2005; 102(50): 17889 - 17890.
[Full Text] [PDF]
Papers of Note
Sci. Aging Knowl. Environ., September 28, 2005; 2005(39): nw36 - nw36.
[Full Text]
|
|
|
|
 |
|