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The Journal of Neuroscience, January 26, 2005, 25(4):936-940; doi:10.1523/JNEUROSCI.4715-04.2005

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BRIEF COMMUNICATION
Cocaine-Induced Plasticity of Intrinsic Membrane Properties in Prefrontal Cortex Pyramidal Neurons: Adaptations in Potassium Currents

Yan Dong,^2,3 Fernando J. Nasif,¹ Jennifer J. Tsui,³ William Y. Ju,³ Donald C. Cooper,¹ Xiu-Ti Hu,¹ Robert C. Malenka,³ and Francis J. White¹

Departments of ¹Cellular and Molecular Pharmacology and ²Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064, and ³Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304-5485

Drug-induced adaptations in the prefrontal cortex (PFC) contribute to several core aspects of addictive behaviors, but the underlying neuronal processes remain essentially unknown. Here, we demonstrate that repeated in vivo exposure to cocaine persistently reduces the voltage-gated K⁺ current (VGKC) in PFC pyramidal neurons, resulting in enhanced membrane excitability. Analysis of dopamine D₁-class receptor (D₁R)-mediated modulation of VGKC indicates that, despite the absence of direct D₁R stimulation, downstream D₁ signaling (the cAMP/protein kinase A pathway) is increased during withdrawal from chronic cocaine treatment and plays a central role in the drug-induced membrane plasticity in PFC. This long-lasting, cocaine-induced plasticity of membrane excitability in PFC pyramidal neurons may contribute to the impaired decision making and drug craving that characterize cocaine withdrawal.

Key words: cocaine; prefrontal cortex; dopamine; K⁺ current; plasticity; adenylate cyclase

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Received Sep 21, 2004; accepted December 6, 2004.

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