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The Journal of Neuroscience, January 26, 2005, 25(4):971-976; doi:10.1523/JNEUROSCI.3489-04.2005

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BRIEF COMMUNICATION
Evidence That Disinhibition Is Associated with a Decrease in Number of Vesicles Available for Release at Inhibitory Synapses

Veronica A. Ledoux and Catherine S. Woolley

Department of Neurobiology and Physiology and Northwestern University Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208

We used three-dimensional reconstruction from serial electron micrographs to investigate two structural changes that could underlie estrogen-induced disinhibition of hippocampal CA1 pyramidal cells: a decrease in the number of inhibitory inputs per neuron and/or a change in inhibitory boutons that could limit GABA release. We analyzed 373 boutons forming 510 inhibitory synapses in estrogentreated and control animals. Our results show that estrogen specifically decreases the number of synaptic vesicles adjacent to the presynaptic membrane of inhibitory synapses without affecting the overall number of vesicles. We detected no difference in the density of inhibitory inputs. These findings provide a novel mechanism for the functional effects of estrogen on synaptic inhibition and represent the first in vivo evidence that the number of presynaptic vesicles available for release is a regulated property of synapses that affects synaptic physiology.

Key words: estrogen; hippocampus; GABA; IPSC; paired-pulse depression; serial reconstruction

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Received Aug 24, 2004; revised December 8, 2004; accepted December 13, 2004.

This article has been cited by other articles:

				S. A. Hart, M. A. Snyder, T. Smejkalova, and C. S. Woolley Estrogen Mobilizes a Subset of Estrogen Receptor-{alpha}-Immunoreactive Vesicles in Inhibitory Presynaptic Boutons in Hippocampal CA1 J. Neurosci., February 21, 2007; 27(8): 2102 - 2111. [Abstract] [Full Text] [PDF]

				P. Guimaraes, S. T. Frisina, F. Mapes, S. F. Tadros, D. R. Frisina, and R. D. Frisina Progestin negatively affects hearing in aged women PNAS, September 19, 2006; 103(38): 14246 - 14249. [Abstract] [Full Text] [PDF]

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