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The Journal of Neuroscience, October 5, 2005, 25(40):9124-9134; doi:10.1523/JNEUROSCI.2648-05.2005

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Cellular/Molecular
Stereotyped Axon Pruning via Plexin Signaling Is Associated with Synaptic Complex Elimination in the Hippocampus

Xiao-Bo Liu,1 * Lawrence K. Low,1 * Edward G. Jones,1,2 and Hwai-Jong Cheng1,3,3

1Center for Neuroscience, 2Department of Psychiatry, and 3Section of Neurobiology, Physiology, and Behavior, 3Department of Pathology and Laboratory Medicine, University of California, Davis, Davis, California 95616

Plexin signaling is required for stereotyped pruning of long axon collaterals in the vertebrate CNS; however, a cellular basis for plexins on stereotyped pruning has not been determined. Using quantitative electron microscopy and immunocytochemistry, we found that infrapyramidal mossy fiber axon collaterals form transient synaptic complexes with basal dendrites of CA3 pyramidal cells in the early postnatal mouse hippocampus. At later postnatal ages, these synaptic complexes stop maturing and are removed before stereotyped pruning by a mechanism that does not involve axon degeneration and glial cell engulfment. In knock-out mice that lack plexin-A3 signaling, the synaptic complexes continue to mature, and, as a result, the collaterals are not pruned. Thus, our results suggest that intact plexin-A3 signaling contributes to synaptic complex elimination, which is associated with stereotyped axon pruning.

Key words: axon pruning; plexin; semaphorin; synaptic complex; mossy fiber; hippocampus; granule cell

Received June 27, 2005; revised August 16, 2005; accepted August 22, 2005.




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