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The Journal of Neuroscience, October 5, 2005, 25(40):9258-9265; doi:10.1523/JNEUROSCI.2112-05.2005

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Cellular/Molecular
Nicotinic Cholinergic Receptors in the Rat Cerebellum: Multiple Heteromeric Subtypes

Jill R. Turner and Kenneth J. Kellar

Department of Pharmacology and Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20057

Nicotinic receptors (nAChRs) in the cerebellum have been implicated in the pathology of autism spectrum disorders (Lee et al., 2002; Martin-Ruiz et al., 2004). The subtypes of nAChRs in the cerebellum are not known in any detail, except that, in addition to the homomeric 7 subtype, there appears to be one or more heteromeric subtypes consisting of combinations of and subunits. To begin to better understand the potential roles of these heteromeric nAChRs in cerebellar circuitry and their potential as targets for nicotinic drugs, we investigated their subunit composition. Using subunit-selective antibodies in sequential immunoprecipitation assays, we detected six structurally distinct heteromeric nAChR populations in the rat cerebellum. Among these were several subtypes that have not been encountered previously, including 342 and 344 nAChRs. This diversity suggests that nAChRs play multiple roles in cerebellar physiology.

Key words: nicotinic receptor; acetylcholine; cerebellum; rat; receptor; antibody

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Received May 25, 2005; revised August 19, 2005; accepted August 27, 2005.

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