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The Journal of Neuroscience, October 26, 2005, 25(43):9978-9988; doi:10.1523/JNEUROSCI.2666-05.2005

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Behavioral/Systems/Cognitive
Two-Dimensional Time Coding in the Auditory Brainstem

Sean J. Slee,¹ Matthew H. Higgs,¹ Adrienne L. Fairhall,¹ and William J. Spain^1,2,3

Departments of ¹Physiology and Biophysics and ²Neurology, University of Washington, Seattle, Washington 98105, and ³Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108

Avian nucleus magnocellularis (NM) spikes provide a temporal code representing sound arrival times to downstream neurons that compute sound source location. NM cells act as high-pass filters by responding only to discrete synaptic events while ignoring temporally summed EPSPs. This high degree of input selectivity insures that each output spike from NM unambiguously represents inputs that contain precise temporal information. However, we lack a quantitative description of the computation performed by NM cells. A powerful model for predicting output firing rate given an arbitrary current input is given by a linear/nonlinear cascade: the stimulus is compared with a known relevant feature by linear filtering, and based on that comparison, a nonlinear function predicts the firing response. Spike-triggered covariance analysis allows us to determine a generalization of this model in which firing depends on more than one spike-triggering feature or stimulus dimension. We found two current features relevant for NM spike generation; the most important simply smooths the current on short time scales, whereas the second confers sensitivity to rapid changes. A model based on these two features captured more mutual information between current and spikes than a model based on a single feature. We used this analysis to characterize the changes in the computation brought about by pharmacological manipulation of the biophysical properties of the neurons. Blockage of low-threshold voltage-gated potassium channels selectively eliminated the requirement for the second stimulus feature, generalizing our understanding of input selectivity by NM cells. This study demonstrates the power of covariance analysis for investigating single neuron computation.

Key words: sound localization; covariance analysis; phase-locking; potassium channel; spike; nucleus magnocellularis

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Received June 28, 2005; revised August 29, 2005; accepted September 20, 2005.

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