QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, February 2, 2005, 25(5):1103-1112; doi:10.1523/JNEUROSCI.3008-04.2005

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (40) Citing Articles via Google Scholar Google Scholar Articles by Berrendero, F. Articles by Maldonado, R. Search for Related Content PubMed PubMed Citation Articles by Berrendero, F. Articles by Maldonado, R.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Nicotine-Induced Antinociception, Rewarding Effects, and Physical Dependence Are Decreased in Mice Lacking the Preproenkephalin Gene

Fernando Berrendero,¹ Victoria Mendizábal,¹ Patricia Robledo,^1,2 Lola Galeote,¹ Andras Bilkei-Gorzo,³ Andreas Zimmer,³ and Rafael Maldonado¹

¹Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, and ²Pharmacology Research Unit, Institut Municipal d'Investigació Mèdica, 08003 Barcelona, Spain, and ³Laboratory of Molecular Neurobiology, Department of Psychiatry, University of Bonn, 53105 Bonn, Germany

It has been shown previously that the endogenous opioid system may be involved in the behavioral effects of nicotine. In the present study, the participation of endogenous enkephalins on nicotine responses has been investigated by using preproenkephalin knock-out mice. Acute nicotine-induced hypolocomotion remained unaffected in these mice. In contrast, antinociception elicited in the tail-immersion and hot-plate tests by acute nicotine administration was reduced in mutant animals. The rewarding properties of nicotine were then investigated using the place-conditioning paradigm. Nicotine induced a conditioned place preference in wild-type animals, but this effect was absent in knock-out mice. Accordingly, in vivo microdialysis studies revealed that the enhancement in dopamine extracellular levels in the nucleus accumbens induced by nicotine was also reduced in preproenkephalin-deficient mice. Finally, the somatic expression of the nicotine withdrawal syndrome precipitated in nicotine-dependent mice by mecamylamine was significantly attenuated in mutant animals. In summary, the present results indicate that endogenous opioid peptides derived from preproenkephalin are involved in the antinociceptive and rewarding properties of nicotine and participate in the expression of physical nicotine dependence.

Key words: nicotine; antinociception; reward; dependence; enkephalin; knock-out mice

---

Received March 15, 2004; revised December 14, 2004; accepted December 14, 2004.

This article has been cited by other articles:

				J. Le Merrer, J. A. J. Becker, K. Befort, and B. L. Kieffer Reward Processing by the Opioid System in the Brain Physiol Rev, October 1, 2009; 89(4): 1379 - 1412. [Abstract] [Full Text] [PDF]

				N. L. Benowitz Nicotine and Postoperative Management of Pain Anesth. Analg., September 1, 2008; 107(3): 739 - 741. [Full Text] [PDF]

				A. Turan, P. F. White, O. Koyuncu, B. Karamanliodlu, G. Kaya, and C. C. Apfel Transdermal Nicotine Patch Failed to Improve Postoperative Pain Management Anesth. Analg., September 1, 2008; 107(3): 1011 - 1017. [Abstract] [Full Text] [PDF]

				M. De Biasi and R. Salas Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal Exp Biol Med, August 1, 2008; 233(8): 917 - 929. [Abstract] [Full Text] [PDF]

				J. P. Britt and D. S. McGehee Presynaptic Opioid and Nicotinic Receptor Modulation of Dopamine Overflow in the Nucleus Accumbens J. Neurosci., February 13, 2008; 28(7): 1672 - 1681. [Abstract] [Full Text] [PDF]

				I. Ferezou, E. L. Hill, B. Cauli, N. Gibelin, T. Kaneko, J. Rossier, and B. Lambolez Extensive Overlap of Mu-Opioid and Nicotinic Sensitivity in Cortical Interneurons Cereb Cortex, August 1, 2007; 17(8): 1948 - 1957. [Abstract] [Full Text] [PDF]

				M. I. Damaj, C. Fonck, M. J. Marks, P. Deshpande, C. Labarca, H. A. Lester, A. C. Collins, and B. R. Martin Genetic Approaches Identify Differential Roles for {alpha}4beta2* Nicotinic Receptors in Acute Models of Antinociception in Mice J. Pharmacol. Exp. Ther., June 1, 2007; 321(3): 1161 - 1169. [Abstract] [Full Text] [PDF]

				H. Zhu, M. Lee, S. Agatsuma, and N. Hiroi Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice Hum. Mol. Genet., April 1, 2007; 16(7): 820 - 836. [Abstract] [Full Text] [PDF]

				S. Agatsuma, M. Lee, H. Zhu, K. Chen, J. C. Shih, I. Seif, and N. Hiroi Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli Hum. Mol. Genet., September 15, 2006; 15(18): 2721 - 2731. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help