 |
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, February 2, 2005, 25(5):1203-1210; doi:10.1523/JNEUROSCI.2540-04.2005
Previous Article | Next Article
Behavioral/Systems/Cognitive
Neural Correlates of Relational Memory: Successful Encoding and Retrieval of Semantic and Perceptual Associations
Steven E. Prince, Sander M. Daselaar, andRoberto Cabeza Center for Cognitive Neuroscience and Department of Psychological and Brain Sciences, Duke University, Durham, North Carolina 27708
Using event-related functional magnetic resonance imaging, we identified brain regions involved in successful relational memory (RM) during encoding and retrieval for semantic and perceptual associations or in general, independent of phase and content. Participants were scanned while encoding and later retrieving associations between pairs of words (semantic RM) or associations between words and fonts (perceptual RM). Encoding success activity (ESA) was identified by comparing study-phase activity for items subsequently remembered (hits) versus forgotten (misses) and retrieval success activity (RSA) by comparing test-phase activity for hits versus misses. The study yielded three main sets of findings. First, ESA-RSA differences were found within the medial temporal lobes (MTLs) and within the prefrontal cortex (PFC). Within the left MTL, ESA was greater in the anterior hippocampus, and RSA was greater in the posterior parahippocampal cortex/hippocampus. This finding is consistent with the notion of an encoding-retrieval gradient along the longitudinal MTL axis. Within the left PFC, ESA was greater in ventrolateral PFC, and RSA was greater in dorsolateral and anterior PFC. This is the first evidence of a dissociation in successful encoding and retrieval activity within left PFC. Second, consistent with the transfer-appropriate processing principle, some ESA regions were reactivated during RSA in a content-specific manner. For semantic RM, these regions included the left ventrolateral PFC, whereas for perceptual RM, they included occipitoparietal and right parahippocampal regions. Finally, only one region in the entire brain was associated with RM in general (i.e., for both semantic and perceptual ESA and RSA): the left hippocampus. This finding highlights the fundamental role of the hippocampus in RM.
Key words: association; hippocampus; memory; prefrontal; event-related fMRI; neuroimaging; encoding; retrieval; context; semantic; perceptual; relational
Received June 25, 2004; revised December 13, 2004; accepted December 19, 2004.
This article has been cited by other articles:
P. M. Paz-Alonso, S. Ghetti, S. E. Donohue, G. S. Goodman, and S. A. Bunge
Neurodevelopmental Correlates of True and False Recognition
Cereb Cortex, September 1, 2008; 18(9): 2208 - 2216.
[Abstract] [Full Text] [PDF]
B. P. Staresina and L. Davachi
Selective and Shared Contributions of the Hippocampus and Perirhinal Cortex to Episodic Item and Associative Encoding
J. Cogn. Neurosci., August 1, 2008; 20(8): 1478 - 1489.
[Abstract] [Full Text] [PDF]
P. St. Jacques, D. C. Rubin, K. S. LaBar, and R. Cabeza
The Short and Long of It: Neural Correlates of Temporal-order Memory for Autobiographical Events
J. Cogn. Neurosci., July 1, 2008; 20(7): 1327 - 1341.
[Abstract] [Full Text] [PDF]
J. D. Ryan, S. N. Moses, M. L. Ostreicher, T. Bardouille, A. T. Herdman, L. Riggs, and E. Tulving
Seeing sounds and hearing sights: the influence of prior learning on current perception.
J. Cogn. Neurosci., June 1, 2008; 20(6): 1030 - 1042.
[Abstract] [Full Text] [PDF]
S. W. Davis, N. A. Dennis, S. M. Daselaar, M. S. Fleck, and R. Cabeza
Que PASA? The Posterior-Anterior Shift in Aging
Cereb Cortex, May 1, 2008; 18(5): 1201 - 1209.
[Abstract] [Full Text] [PDF]
P. Koenig, E. E. Smith, V. Troiani, C. Anderson, P. Moore, and M. Grossman
Medial Temporal Lobe Involvement in an Implicit Memory Task: Evidence of Collaborating Implicit and Explicit Memory Systems from fMRI and Alzheimer's Disease
Cereb Cortex, April 9, 2008; (2008) bhn043v1.
[Abstract] [Full Text] [PDF]
S. M. Daselaar, H. J. Rice, D. L. Greenberg, R. Cabeza, K. S. LaBar, and D. C. Rubin
The Spatiotemporal Dynamics of Autobiographical Memory: Neural Correlates of Recall, Emotional Intensity, and Reliving
Cereb Cortex, January 1, 2008; 18(1): 217 - 229.
[Abstract] [Full Text] [PDF]
M. G. Philiastides and P. Sajda
EEG-Informed fMRI Reveals Spatiotemporal Characteristics of Perceptual Decision Making
J. Neurosci., November 28, 2007; 27(48): 13082 - 13091.
[Abstract] [Full Text] [PDF]
R. J. Garoff-Eaton, E. A. Kensinger, and D. L. Schacter
The neural correlates of conceptual and perceptual false recognition
Learn. Mem., October 1, 2007; 14(10): 684 - 692.
[Abstract] [Full Text] [PDF]
H. Burianova and C. L. Grady
Common and unique neural activations in autobiographical, episodic, and semantic retrieval.
J. Cogn. Neurosci., September 1, 2007; 19(9): 1520 - 1534.
[Abstract] [Full Text] [PDF]
H. Kim and R. Cabeza
Differential Contributions of Prefrontal, Medial Temporal, and Sensory-Perceptual Regions to True and False Memory Formation
Cereb Cortex, September 1, 2007; 17(9): 2143 - 2150.
[Abstract] [Full Text] [PDF]
R. S. Blumenfeld and C. Ranganath
Prefrontal Cortex and Long-Term Memory Encoding: An Integrative Review of Findings from Neuropsychology and Neuroimaging
Neuroscientist, June 1, 2007; 13(3): 280 - 291.
[Abstract] [PDF]
L. J. Murray and C. Ranganath
The Dorsolateral Prefrontal Cortex Contributes to Successful Relational Memory Encoding
J. Neurosci., May 16, 2007; 27(20): 5515 - 5522.
[Abstract] [Full Text] [PDF]
M. Abe, T. Hanakawa, Y. Takayama, C. Kuroki, S. Ogawa, and H. Fukuyama
Functional Coupling of Human Prefrontal and Premotor Areas during Cognitive Manipulation
J. Neurosci., March 28, 2007; 27(13): 3429 - 3438.
[Abstract] [Full Text] [PDF]
S. M. Daselaar, M. S. Fleck, and R. Cabeza
Triple Dissociation in the Medial Temporal Lobes: Recollection, Familiarity, and Novelty
J Neurophysiol, October 1, 2006; 96(4): 1902 - 1911.
[Abstract] [Full Text] [PDF]
M. Smits, E. Visch-Brink, C. K. Schraa-Tam, P. J. Koudstaal, and A. van der Lugt
Functional MR Imaging of Language Processing: An Overview of Easy-to-Implement Paradigms for Patient Care and Clinical Research
RadioGraphics, October 1, 2006; 26(suppl_1): S145 - S158.
[Abstract] [Full Text] [PDF]
K. Sergerie, M. Lepage, and J. L. Armony
A Process-specific Functional Dissociation of the Amygdala in Emotional Memory.
J. Cogn. Neurosci., August 1, 2006; 18(8): 1359 - 1367.
[Abstract] [Full Text] [PDF]
S. M. Daselaar, M. S. Fleck, S. E. Prince, and R. Cabeza
The Medial Temporal Lobe Distinguishes Old from New Independently of Consciousness
J. Neurosci., May 24, 2006; 26(21): 5835 - 5839.
[Abstract] [Full Text] [PDF]
D. Ongur, T. J. Cullen, D. H. Wolf, M. Rohan, P. Barreira, M. Zalesak, and S. Heckers
The neural basis of relational memory deficits in schizophrenia.
Arch Gen Psychiatry, April 1, 2006; 63(4): 356 - 365.
[Abstract] [Full Text] [PDF]
E. A. Kensinger and D. L. Schacter
Amygdala Activity Is Associated with the Successful Encoding of Item, But Not Source, Information for Positive and Negative Stimuli
J. Neurosci., March 1, 2006; 26(9): 2564 - 2570.
[Abstract] [Full Text] [PDF]
R. S. Blumenfeld and C. Ranganath
Dorsolateral Prefrontal Cortex Promotes Long-Term Memory Formation through Its Role in Working Memory Organization
J. Neurosci., January 18, 2006; 26(3): 916 - 925.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|