WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, February 2, 2005, 25(5):1304-1310; doi:10.1523/JNEUROSCI.4745.04.2005

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (69)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, H.
Right arrow Articles by Caterina, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, H.
Right arrow Articles by Caterina, M. J.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4

Hyosang Lee,1 Tohko Iida,1 Atsuko Mizuno,2 Makoto Suzuki,2 and Michael J. Caterina1

1Departments of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and 2Department of Pharmacology, Jichi Medical School, Mimamikawachi, Tochigi 329-0498, Japan

Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4-/- mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia. However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions. We therefore investigated the contribution of TRPV4 to thermosensation and thermoregulation in vivo. On a thermal gradient, TRPV4-/- mice selected warmer floor temperatures than wild-type littermates. In addition, whereas wild-type mice failed to discriminate between floor temperatures of 30 and 34°C, TRPV4-/- mice exhibited a strong preference for 34°C. TRPV4-/- mice also exhibited prolonged withdrawal latencies during acute tail heating. TRPV4-/- and wild-type mice exhibited similar changes in behavior on a thermal gradient after paw inflammation. Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness in vivo.

Key words: TRPV4; thermosensation; warm; heat; temperature; pain

Received Aug 19, 2004; revised December 23, 2004; accepted December 23, 2004.




This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
P. L. Tan and N. Katsanis
Thermosensory and mechanosensory perception in human genetic disease
Hum. Mol. Genet., October 15, 2009; 18(R2): R146 - R155.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. A. Romanovsky, M. C. Almeida, A. Garami, A. A. Steiner, M. H. Norman, S. F. Morrison, K. Nakamura, J. J. Burmeister, and T. B. Nucci
The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not
Pharmacol. Rev., September 1, 2009; 61(3): 228 - 261.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Earley, T. Pauyo, R. Drapp, M. J. Tavares, W. Liedtke, and J. E. Brayden
TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure
Am J Physiol Heart Circ Physiol, September 1, 2009; 297(3): H1096 - H1102.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Imamachi, G. H. Park, H. Lee, D. J. Anderson, M. I. Simon, A. I. Basbaum, and S.-K. Han
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms
PNAS, July 7, 2009; 106(27): 11330 - 11335.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. J. Cavanaugh, H. Lee, L. Lo, S. D. Shields, M. J. Zylka, A. I. Basbaum, and D. J. Anderson
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
PNAS, June 2, 2009; 106(22): 9075 - 9080.
[Abstract] [Full Text] [PDF]

Home page
 J PsychopharmacolHome page
C. Lowry, S. Lightman, and D. Nutt
That warm fuzzy feeling: brain serotonergic neurons and the regulation of emotion
J Psychopharmacol, June 1, 2009; 23(4): 392 - 400.
[Abstract] [PDF]

Home page
 HypertensionHome page
F. Gao, D. Sui, R. M. Garavito, R. M. Worden, and D. H. Wang
Salt Intake Augments Hypotensive Effects of Transient Receptor Potential Vanilloid 4: Functional Significance and Implication
Hypertension, February 1, 2009; 53(2): 228 - 235.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Wegierski, U. Lewandrowski, B. Muller, A. Sickmann, and G. Walz
Tyrosine Phosphorylation Modulates the Activity of TRPV4 in Response to Defined Stimuli
J. Biol. Chem., January 30, 2009; 284(5): 2923 - 2933.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. M. Huang, H. Lee, M.-K. Chung, U. Park, Y. Y. Yu, H. B. Bradshaw, P. A. Coulombe, J. M. Walker, and M. J. Caterina
Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2
J. Neurosci., December 17, 2008; 28(51): 13727 - 13737.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Kottgen, B. Buchholz, M. A. Garcia-Gonzalez, F. Kotsis, X. Fu, M. Doerken, C. Boehlke, D. Steffl, R. Tauber, T. Wegierski, et al.
TRPP2 and TRPV4 form a polymodal sensory channel complex
J. Cell Biol., August 11, 2008; 182(3): 437 - 447.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. S. Thorneloe, A. C. Sulpizio, Z. Lin, D. J. Figueroa, A. K. Clouse, G. P. McCafferty, T. P. Chendrimada, E. S. R. Lashinger, E. Gordon, L. Evans, et al.
N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I
J. Pharmacol. Exp. Ther., August 1, 2008; 326(2): 432 - 442.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. F. Morrison, K. Nakamura, and C. J. Madden
Central control of thermogenesis in mammals
Exp Physiol, July 1, 2008; 93(7): 773 - 797.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. D'hoedt, G. Owsianik, J. Prenen, M. P. Cuajungco, C. Grimm, S. Heller, T. Voets, and B. Nilius
Stimulus-specific Modulation of the Cation Channel TRPV4 by PACSIN 3
J. Biol. Chem., March 7, 2008; 283(10): 6272 - 6280.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
H. Yamashita, Z. Wang, Y. Wang, T. Furuyama, Y. Kontani, Y. Sato, and N. Mori
Impaired Basal Thermal Homeostasis in Rats Lacking Capsaicin-sensitive Peripheral Small Sensory Neurons
J. Biochem., March 1, 2008; 143(3): 385 - 393.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. Birder, F. A. Kullmann, H. Lee, S. Barrick, W. de Groat, A. Kanai, and M. Caterina
Activation of Urothelial Transient Receptor Potential Vanilloid 4 by 4{alpha}-Phorbol 12,13-Didecanoate Contributes to Altered Bladder Reflexes in the Rat
J. Pharmacol. Exp. Ther., October 1, 2007; 323(1): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. A. Steiner, V. F. Turek, M. C. Almeida, J. J. Burmeister, D. L. Oliveira, J. L. Roberts, A. W. Bannon, M. H. Norman, J.-C. Louis, J. J. S. Treanor, et al.
Nonthermal Activation of Transient Receptor Potential Vanilloid-1 Channels in Abdominal Viscera Tonically Inhibits Autonomic Cold-Defense Effectors
J. Neurosci., July 11, 2007; 27(28): 7459 - 7468.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. R. Gavva, A. W. Bannon, S. Surapaneni, D. N. Hovland Jr, S. G. Lehto, A. Gore, T. Juan, H. Deng, B. Han, L. Klionsky, et al.
The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation
J. Neurosci., March 28, 2007; 27(13): 3366 - 3374.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. D. Grant, G. S. Cottrell, S. Amadesi, M. Trevisani, P. Nicoletti, S. Materazzi, C. Altier, N. Cenac, G. W. Zamponi, F. Bautista-Cruz, et al.
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
J. Physiol., February 1, 2007; 578(3): 715 - 733.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Kiselyov, A. Soyombo, and S. Muallem
TRPpathies
J. Physiol., February 1, 2007; 578(3): 641 - 653.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. Caterina
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R64 - R76.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. A. Romanovsky
Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R37 - R46.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
S. Saito and R. Shingai
Evolution of thermoTRP ion channel homologs in vertebrates
Physiol Genomics, November 21, 2006; 27(3): 219 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. F. Alvarez, J. A. King, D. Weber, E. Addison, W. Liedtke, and M. I. Townsley
Transient Receptor Potential Vanilloid 4-Mediated Disruption of the Alveolar Septal Barrier: A Novel Mechanism of Acute Lung Injury
Circ. Res., October 27, 2006; 99(9): 988 - 995.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. L. Smith, K. N. Maloney, R. G. Pothen, J. Clardy, and D. E. Clapham
Bisandrographolide from Andrographis paniculata Activates TRPV4 Channels
J. Biol. Chem., October 6, 2006; 281(40): 29897 - 29904.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. H. Lindfors, V. Voikar, J. Rossi, and M. S. Airaksinen
Deficient Nonpeptidergic Epidermis Innervation and Reduced Inflammatory Pain in Glial Cell Line-Derived Neurotrophic Factor Family Receptor {alpha}2 Knock-Out Mice
J. Neurosci., February 15, 2006; 26(7): 1953 - 1960.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Vriens, G. Owsianik, B. Fisslthaler, M. Suzuki, A. Janssens, T. Voets, C. Morisseau, B.D. Hammock, I. Fleming, R. Busse, et al.
Modulation of the Ca2 Permeable Cation Channel TRPV4 by Cytochrome P450 Epoxygenases in Vascular Endothelium
Circ. Res., October 28, 2005; 97(9): 908 - 915.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
B. Nilius, T. Voets, and J. Peters
TRP Channels in Disease
Sci. Signal., August 2, 2005; 2005(295): re8 - re8.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-