QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, February 9, 2005, 25(6):1599-1609; doi:10.1523/JNEUROSCI.4457-04.2005

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (25) Citing Articles via Google Scholar Google Scholar Articles by Alvarado, M. C. Articles by Bachevalier, J. Search for Related Content PubMed PubMed Citation Articles by Alvarado, M. C. Articles by Bachevalier, J.

 Previous Article

Behavioral/Systems/Cognitive
Comparison of the Effects of Damage to the Perirhinal and Parahippocampal Cortex on Transverse Patterning and Location Memory in Rhesus Macaques

Maria C. Alvarado and Jocelyne Bachevalier

Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas 77030

Monkeys with damage to the parahippocampal (TH/TF) or perirhinal (PRh) cortex were tested on two sets of the transverse patterning (TP) problem (A+/B-, B+/C-, C+/A- and D+/E-, E+/F-, F+/D-) and delayed nonmatching-to-location paradigm (DNML), with delays ranging from 10 to 600 s. Damage to either area impaired acquisition and performance of TP but not of linear discriminations (e.g., A>B>C>X). Damage to areas TH/TF impaired performance of the DNML at all delays but only affected memory for objects at the longest delay, as measured by a delayed nonmatching-to-sample task (DNMS) (Nemanic et al., 2004). Damage to the PRh impaired performance of the DNMS but not of the DNML. The results present a dissociation in object and place memory for these two cortical regions and suggest a role for each in the cortical circuitry supporting configural/relational memory.

Key words: configural memory; relational memory; discrimination learning; spatial memory; recognition memory; temporal lobe

---

Received Oct 29, 2004; revised December 7, 2004; accepted December 31, 2004.

This article has been cited by other articles:

				S. R. Lehky and K. Tanaka Enhancement of Object Representations in Primate Perirhinal Cortex During a Visual Working-Memory Task J Neurophysiol, February 1, 2007; 97(2): 1298 - 1310. [Abstract] [Full Text] [PDF]

				L. M. Saksida, T. J. Bussey, C. A. Buckmaster, and E. A. Murray Impairment and Facilitation of Transverse Patterning after Lesions of the Perirhinal Cortex and Hippocampus, Respectively Cereb Cortex, January 1, 2007; 17(1): 108 - 115. [Abstract] [Full Text] [PDF]

				D. Yoganarasimha, X. Yu, and J. J. Knierim Head Direction Cell Representations Maintain Internal Coherence during Conflicting Proximal and Distal Cue Rotations: Comparison with Hippocampal Place Cells J. Neurosci., January 11, 2006; 26(2): 622 - 631. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help