 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, March 2, 2005, 25(9):2429-2433; doi:10.1523/JNEUROSCI.4925-04.2005
Previous Article | Next Article
BRIEF COMMUNICATION
Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin Neurons In Situ
Denis Burdakov,1 Oleg Gerasimenko,2 andAlexei Verkhratsky1 1Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom, and 2Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
The physiological signaling mechanisms that link normal variations in body energy status to the activity of arousal- and metabolism-regulating brain centers are not well understood. The melanin-concentrating hormone (MCH) and orexin/hypocretin types of neurons of the lateral hypothalamus (LH) exert opposing effects on arousal and metabolism. We examined whether shifts in brain extracellular glucose that correspond to physiological changes in blood glucose can alter the electrical output of neurochemically and biophysically defined LH cells in mouse brain slices. Here, we show that physiologically relevant concentrations of glucose dose-dependently enhance the electrical excitability of MCH neurons by inducing depolarization and increasing membrane resistance. We also demonstrate that the same physiological shifts in glucose have the opposite effects on the electrical activity of orexin neurons. We propose that these direct actions of glucose on the arousal- and metabolism-regulating LH neurons play a key role in the translation of normal variations in body energy resources into appropriate changes in arousal and metabolism.
Key words: sleep; wakefulness; feeding; glucose; orexin; hypocretin; melanin-concentrating hormone
Received Dec 3, 2004; revised January 18, 2005; accepted January 24, 2005.
This article has been cited by other articles:
N. Tsujino and T. Sakurai
Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System
Pharmacol. Rev., June 1, 2009; 61(2): 162 - 176.
[Abstract] [Full Text] [PDF]
J. Hara, D. Gerashchenko, J. P. Wisor, T. Sakurai, X. Xie, and T. S. Kilduff
Thyrotropin-Releasing Hormone Increases Behavioral Arousal through Modulation of Hypocretin/Orexin Neurons
J. Neurosci., March 25, 2009; 29(12): 3705 - 3714.
[Abstract] [Full Text] [PDF]
A. Guyon, M. P. Tardy, C. Rovere, J.-L. Nahon, J. Barhanin, and F. Lesage
Glucose Inhibition Persists in Hypothalamic Neurons Lacking Tandem-Pore K+ Channels
J. Neurosci., February 25, 2009; 29(8): 2528 - 2533.
[Abstract] [Full Text] [PDF]
A. Y. Zecharia, L. E. Nelson, T. C. Gent, M. Schumacher, R. Jurd, U. Rudolph, S. G. Brickley, M. Maze, and N. P. Franks
The Involvement of Hypothalamic Sleep Pathways in General Anesthesia: Testing the Hypothesis Using the GABAA Receptor {beta}3N265M Knock-In Mouse
J. Neurosci., February 18, 2009; 29(7): 2177 - 2187.
[Abstract] [Full Text] [PDF]
O. K. Hassani, M. G. Lee, and B. E. Jones
Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
PNAS, February 17, 2009; 106(7): 2418 - 2422.
[Abstract] [Full Text] [PDF]
J. A. Gonzalez, F. Reimann, and D. Burdakov
Dissociation between sensing and metabolism of glucose in sugar sensing neurones
J. Physiol., January 1, 2009; 587(1): 41 - 48.
[Abstract] [Full Text] [PDF]
A. Adamantidis and L. de Lecea
The hypocretins as sensors for metabolism and arousal
J. Physiol., January 1, 2009; 587(1): 33 - 40.
[Abstract] [Full Text] [PDF]
J. A. Gonzalez, L. T. Jensen, L. Fugger, and D. Burdakov
Metabolism-Independent Sugar Sensing in Central Orexin Neurons
Diabetes, October 1, 2008; 57(10): 2569 - 2576.
[Abstract] [Full Text] [PDF]
R. H. Williams, H. Alexopoulos, L. T. Jensen, L. Fugger, and D. Burdakov
Adaptive sugar sensors in hypothalamic feeding circuits
PNAS, August 19, 2008; 105(33): 11975 - 11980.
[Abstract] [Full Text] [PDF]
B.-S. Deng, A. Nakamura, W. Zhang, M. Yanagisawa, Y. Fukuda, and T. Kuwaki
Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice
J Appl Physiol, November 1, 2007; 103(5): 1772 - 1779.
[Abstract] [Full Text] [PDF]
R. Ducroc, T. Voisin, A. El Firar, and M. Laburthe
Orexins Control Intestinal Glucose Transport by Distinct Neuronal, Endocrine, and Direct Epithelial Pathways
Diabetes, October 1, 2007; 56(10): 2494 - 2500.
[Abstract] [Full Text] [PDF]
R. H. Williams, L. T. Jensen, A. Verkhratsky, L. Fugger, and D. Burdakov
Control of hypothalamic orexin neurons by acid and CO2
PNAS, June 19, 2007; 104(25): 10685 - 10690.
[Abstract] [Full Text] [PDF]
P. D. Mountjoy and G. A. Rutter
Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?
Exp Physiol, March 1, 2007; 92(2): 311 - 319.
[Abstract] [Full Text] [PDF]
A. Nakamura, W. Zhang, M. Yanagisawa, Y. Fukuda, and T. Kuwaki
Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice
J Appl Physiol, January 1, 2007; 102(1): 241 - 248.
[Abstract] [Full Text] [PDF]
B. E. Levin, L. Kang, N. M. Sanders, and A. A. Dunn-Meynell
Role of Neuronal Glucosensing in the Regulation of Energy Homeostasis
Diabetes, December 1, 2006; 55(Supplement_2): S122 - S130.
[Abstract] [Full Text] [PDF]
P. Pissios, R. L. Bradley, and E. Maratos-Flier
Expanding the Scales: The Multiple Roles of MCH in Regulating Energy Balance and Other Biological Functions
Endocr. Rev., October 1, 2006; 27(6): 606 - 620.
[Abstract] [Full Text] [PDF]
B. E. Levin
Orexins: neuropeptides for all seasons and functions
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R885 - R888.
[Full Text] [PDF]
D. Burdakov, S. M Luckman, and A. Verkhratsky
Glucose-sensing neurons of the hypothalamus
Phil Trans R Soc B, December 29, 2005; 360(1464): 2227 - 2235.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|