WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience MBF Bioscience Neurolucida
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, January 4, 2006, 26(1):3-11; doi:10.1523/JNEUROSCI.3648-05.2006

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (81)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhao, C.
Right arrow Articles by Gage, F. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhao, C.
Right arrow Articles by Gage, F. H.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus

Chunmei Zhao, E. Matthew Teng, Robert G. Summers, Jr, Guo-li Ming, and Fred H. Gage

Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037

Adult neurogenesis in the dentate gyrus may contribute to hippocampus-dependent functions, yet little is known about when and how newborn neurons are functional because of limited information about the time course of their connectivity. By using retrovirus-mediated gene transduction, we followed the dendritic and axonal growth of adult-born neurons in the mouse dentate gyrus and identified distinct morphological stages that may indicate different levels of connectivity. Axonal projections of newborn neurons reach the CA3 area 10–11 d after viral infection, 5–6 d before the first spines are formed. Quantitative analyses show that the peak of spine growth occurs during the first 3–4 weeks, but further structural modifications of newborn neurons take place for months. Moreover, the morphological maturation is differentially affected by age and experience, as shown by comparisons between adult and postnatal brains and between housing conditions. Our study reveals the key morphological transitions of newborn granule neurons during their course of maturation.

Key words: neurogenesis; spines; mushroom spines; spine motility; neuronal development; plasticity

Received Aug 27, 2005; revised October 23, 2005; accepted October 29, 2005.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
B. J. Bhattacharyya, G. Banisadr, H. Jung, D. Ren, D. G. Cronshaw, Y. Zou, and R. J. Miller
The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate Gyrus
J. Neurosci., June 25, 2008; 28(26): 6720 - 6730.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. V. Ermini, S. Grathwohl, R. Radde, M. Yamaguchi, M. Staufenbiel, T. D. Palmer, and M. Jucker
Neurogenesis and Alterations of Neural Stem Cells in Mouse Models of Cerebral Amyloidosis
Am. J. Pathol., June 1, 2008; 172(6): 1520 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. R. Bower and P. S. Buckmaster
Changes in Granule Cell Firing Rates Precede Locally Recorded Spontaneous Seizures by Minutes in an Animal Model of Temporal Lobe Epilepsy
J Neurophysiol, May 1, 2008; 99(5): 2431 - 2442.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Gao, P. Arlotta, J. D. Macklis, and J. Chen
Conditional Knock-Out of -Catenin in Postnatal-Born Dentate Gyrus Granule Neurons Results in Dendritic Malformation
J. Neurosci., December 26, 2007; 27(52): 14317 - 14325.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. J. Breunig, J. Silbereis, F. M. Vaccarino, N. Sestan, and P. Rakic
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
PNAS, December 18, 2007; 104(51): 20558 - 20563.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Ninkovic, T. Mori, and M. Gotz
Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis
J. Neurosci., October 3, 2007; 27(40): 10906 - 10911.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
A. K. Shetty and B. Hattiangady
Concise Review: Prospects of Stem Cell Therapy for Temporal Lobe Epilepsy
Stem Cells, October 1, 2007; 25(10): 2396 - 2407.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. C. Whitman and C. A. Greer
Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits
J. Neurosci., September 12, 2007; 27(37): 9951 - 9961.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Jessberger, C. Zhao, N. Toni, G. D. Clemenson Jr, Y. Li, and F. H. Gage
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling
J. Neurosci., August 29, 2007; 27(35): 9400 - 9407.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Walter, B. L. Murphy, R. Y. K. Pun, A. L. Spieles-Engemann, and S. C. Danzer
Pilocarpine-Induced Seizures Cause Selective Time-Dependent Changes to Adult-Generated Hippocampal Dentate Granule Cells
J. Neurosci., July 11, 2007; 27(28): 7541 - 7552.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Verret, J. L. Jankowsky, G. M. Xu, D. R. Borchelt, and C. Rampon
Alzheimer's-Type Amyloidosis in Transgenic Mice Impairs Survival of Newborn Neurons Derived from Adult Hippocampal Neurogenesis
J. Neurosci., June 20, 2007; 27(25): 6771 - 6780.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. van Praag, M. J. Lucero, G. W. Yeo, K. Stecker, N. Heivand, C. Zhao, E. Yip, M. Afanador, H. Schroeter, J. Hammerstone, et al.
Plant-Derived Flavanol (-)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
J. Neurosci., May 30, 2007; 27(22): 5869 - 5878.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
S. Jessberger, G. D. Clemenson Jr, and F. H. Gage
Spontaneous Fusion and Nonclonal Growth of Adult Neural Stem Cells
Stem Cells, April 1, 2007; 25(4): 871 - 874.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Tashiro, H. Makino, and F. H. Gage
Experience-Specific Functional Modification of the Dentate Gyrus through Adult Neurogenesis: A Critical Period during an Immature Stage
J. Neurosci., March 21, 2007; 27(12): 3252 - 3259.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Leuner, J. Waddell, E. Gould, and T. J. Shors
Temporal Discontiguity Is neither Necessary nor Sufficient for Learning-Induced Effects on Adult Neurogenesis
J. Neurosci., December 27, 2006; 26(52): 13437 - 13442.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
V. C. Piatti, M. S. Esposito, and A. F. Schinder
The Timing of Neuronal Development in Adult Hippocampal Neurogenesis
Neuroscientist, December 1, 2006; 12(6): 463 - 468.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
B. Draganski, C. Gaser, G. Kempermann, H. G. Kuhn, J. Winkler, C. Buchel, and A. May
Temporal and spatial dynamics of brain structure changes during extensive learning.
J. Neurosci., June 7, 2006; 26(23): 6314 - 6317.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Bruel-Jungerman, S. Davis, C. Rampon, and S. Laroche
Long-term potentiation enhances neurogenesis in the adult dentate gyrus.
J. Neurosci., May 31, 2006; 26(22): 5888 - 5893.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. S. Overstreet-Wadiche, A. L. Bensen, and G. L. Westbrook
Delayed development of adult-generated granule cells in dentate gyrus.
J. Neurosci., February 22, 2006; 26(8): 2326 - 2334.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-