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The Journal of Neuroscience, January 4, 2006, 26(1):51-62; doi:10.1523/JNEUROSCI.2939-05.2006
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Development/Plasticity/Repair
Hypothalamic Tumor Necrosis Factor- Converting Enzyme Mediates Excitatory Amino Acid-Dependent Neuron-to-Glia Signaling in the Neuroendocrine Brain
Alejandro Lomniczi,
Anda Cornea,
Maria E. Costa, and
Sergio R. Ojeda
Division of Neuroscience, Oregon National Primate Research Center/Oregon Health and Science University, Beaverton, Oregon 97006
Glial erbB1 receptors play a significant role in the hypothalamic control of female puberty. Activation of these receptors by transforming growth factor  (TGF) results in production of prostaglandin E2, which then stimulates luteinizing hormone releasing hormone (LHRH) neurons to secrete LHRH, the neuropeptide controlling sexual development. Glutamatergic neurons set in motion this glia-to-neuron signaling pathway by transactivating erbB1 receptors via coactivation of AMPA receptors (AMPARs) and metabotropic glutamate receptors (mGluRs). Because the metalloproteinase tumor necrosis factor converting enzyme (TACE) releases TGF from its transmembrane precursor before TGF can bind to erbB1 receptors, we sought to determine whether TACE is required for excitatory amino acids to activate the TGF–erbB1 signaling module in hypothalamic astrocytes, and thus facilitate the advent of puberty. Coactivation of astrocytic AMPARs and mGluRs caused extracellular Ca2+ influx, a Ca2+/protein kinase C-dependent increase in TACE-like activity, and enhanced release of TGF. Within the hypothalamus, TACE is most abundantly expressed in astrocytes of the median eminence (ME), and its enzymatic activity increases selectively in this region at the time of the first preovulatory surge of gonadotropins. ME explants respond to stimulation of AMPARs and mGluRs with LHRH release, and this response is prevented by blocking TACE activity. In vivo inhibition of TACE activity targeted to the ME delayed the age at first ovulation, indicating that ME-specific changes in TACE activity are required for the normal timing of puberty. These results suggest that TACE is a component of the neuron-to-glia signaling process used by glutamatergic neurons to control female sexual development.
Key words: TGF; astrocytes; ectodomain shedding; proteolytic cleavage; female puberty; hypothalamus
Received July 15, 2005;
revised October 28, 2005;
accepted November 3, 2005.
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