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The Journal of Neuroscience, March 15, 2006, 26(11):2964-2970; doi:10.1523/JNEUROSCI.2921-05.2006
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Behavioral/Systems/Cognitive
Lateralization of the Human Mirror Neuron System
Lisa Aziz-Zadeh,1,2 Lisa Koski,1,5 Eran Zaidel,2,4 John Mazziotta,1,4,5,6,7 andMarco Iacoboni1,3,4 1Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute, 2Department of Psychology, 3Department of Psychiatry and Biobehavioral Sciences, 4Brain Research Institute, David Geffen School of Medicine, and Departments of 5Neurology, 6Pharmacology, and 7Radiological Sciences, University of California, Los Angeles, Los Angeles, California 90095
Correspondence should be addressed to Lisa Aziz-Zadeh, Ahmanson Lovelace Brain Mapping Center, CA, 660 Charles E. Young Drive South, Los Angeles, CA 90095-7085. Email: lsa{at}ucla.edu
A cortical network consisting of the inferior frontal, rostral inferior parietal, and posterior superior temporal cortices has been implicated in representing actions in the primate brain and is critical to imitation in humans. This neural circuitry may be an evolutionary precursor of neural systems associated with language. However, language is predominantly lateralized to the left hemisphere, whereas the degree of lateralization of the imitation circuitry in humans is unclear. We conducted a functional magnetic resonance imaging study of imitation of finger movements with lateralized stimuli and responses. During imitation, activity in the inferior frontal and rostral inferior parietal cortex, although fairly bilateral, was stronger in the hemisphere ipsilateral to the visual stimulus and response hand. This ipsilateral pattern is at variance with the typical contralateral activity of primary visual and motor areas. Reliably increased signal in the right superior temporal sulcus (STS) was observed for both left-sided and right-sided imitation tasks, although subthreshold activity was also observed in the left STS. Overall, the data indicate that visual and motor components of the human mirror system are not left-lateralized. The left hemisphere superiority for language, then, must be have been favored by other types of language precursors, perhaps auditory or multimodal action representations.
Key words: motor; sensorimotor; premotor; language; hemisphere; lateralization
Received March 10, 2005; revised Jan. 17, 2006; accepted Jan. 18, 2006.
Correspondence should be addressed to Lisa Aziz-Zadeh, Ahmanson Lovelace Brain Mapping Center, CA, 660 Charles E. Young Drive South, Los Angeles, CA 90095-7085. Email: lsa{at}ucla.edu
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