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The Journal of Neuroscience, May 17, 2006, 26(20):5360-5369; doi:10.1523/JNEUROSCI.4853-05.2006

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Behavioral/Systems/Cognitive
Role of Dopamine in the Primate Caudate Nucleus in Reward Modulation of Saccades

Kae Nakamura and Okihide Hikosaka

Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-4435

Correspondence should be addressed to Kae Nakamura, Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Building 49, Room 2A50, 49 Convent Drive, Bethesda, MD 20892-4435. Email: kae{at}lsr.nei.nih.gov

Expected reward impacts behavior and neuronal activity in brain areas involved in sensorimotor processes. However, where and how reward signals affect sensorimotor signals is unclear. Here, we show evidence that reward-dependent modulation of behavior depends on normal dopamine transmission in the striatum. Monkeys performed a visually guided saccade task in which expected reward gain was different depending on the position of the target. Saccadic reaction times were reliably shorter on large-reward trials than on small-reward trials. When position–reward contingency was switched, the reaction time difference changed rapidly. Injecting dopamine D₁ antagonist into the caudate significantly attenuated the reward-dependent saccadic reaction time changes. Conversely, injecting D₂ antagonist into the same region enhanced the reward-dependent changes. These results suggest that reward-dependent changes in saccadic eye movements depend partly on dopaminergic modulation of neuronal activity in the caudate nucleus.

Key words: basal ganglia; caudate; saccade; dopamine; reward; primate

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Received Nov. 10, 2005; revised March 30, 2006; accepted April 3, 2006.

Correspondence should be addressed to Kae Nakamura, Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Building 49, Room 2A50, 49 Convent Drive, Bethesda, MD 20892-4435. Email: kae{at}lsr.nei.nih.gov

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