QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, May 17, 2006, 26(20):5428-5437; doi:10.1523/JNEUROSCI.5284-05.2006

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by Rancz, E. A. Articles by Häusser, M. Search for Related Content PubMed PubMed Citation Articles by Rancz, E. A. Articles by Häusser, M.

 Previous Article  |  Next Article 

Cellular/Molecular
Dendritic Calcium Spikes Are Tunable Triggers of Cannabinoid Release and Short-Term Synaptic Plasticity in Cerebellar Purkinje Neurons

Ede A. Rancz and Michael Häusser

Wolfson Institute for Biomedical Research and Department of Physiology, University College London, London WC1E 6BT, United Kingdom

Correspondence should be addressed to Michael Häusser, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kingdom. Email: m.hausser{at}ucl.ac.uk

Understanding the relationship between dendritic excitability and synaptic plasticity is vital for determining how dendrites regulate the input–output function of the neuron. Dendritic calcium spikes have been associated with the induction of long-term changes in synaptic efficacy. Here we use direct recordings from cerebellar Purkinje cell dendrites to show that synaptically activated local dendritic calcium spikes are potent triggers of cannabinoid release, producing a profound and short-term reduction in synaptic efficacy at parallel fiber synapses. Enhancing dendritic excitability by modulating dendritic large-conductance calcium-activated potassium (BK) channels improves the spread of dendritic calcium spikes and enhances cannabinoid release at the expense of spatial specificity. Our findings reveal that dendritic calcium spikes provide a local and tunable coincidence detection mechanism that readjusts synaptic gain when synchronous activity reaches a threshold, and they reveal a tight link between the regulation of dendritic excitability and the induction of synaptic plasticity.

Key words: dendritic spike; endocannabinoid; BK channel; DSE; Purkinje cell; cerebellum

---

Received Dec. 11, 2005; revised April 10, 2006; accepted April 10, 2006.

Correspondence should be addressed to Michael Häusser, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kingdom. Email: m.hausser{at}ucl.ac.uk

This article has been cited by other articles:

				J. B. Castro and N. N. Urban Subthreshold Glutamate Release from Mitral Cell Dendrites J. Neurosci., May 27, 2009; 29(21): 7023 - 7030. [Abstract] [Full Text] [PDF]

				A. O. Komendantov and G. A. Ascoli Dendritic Excitability and Neuronal Morphology as Determinants of Synaptic Efficacy J Neurophysiol, April 1, 2009; 101(4): 1847 - 1866. [Abstract] [Full Text] [PDF]

				M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe Endocannabinoid-Mediated Control of Synaptic Transmission Physiol Rev, January 1, 2009; 89(1): 309 - 380. [Abstract] [Full Text] [PDF]

				H. Berkefeld and B. Fakler Repolarizing Responses of BKCa-Cav Complexes Are Distinctly Shaped by Their Cav Subunits J. Neurosci., August 13, 2008; 28(33): 8238 - 8245. [Abstract] [Full Text] [PDF]

				J. T. Davie, B. A. Clark, and M. Hausser The Origin of the Complex Spike in Cerebellar Purkinje Cells J. Neurosci., July 23, 2008; 28(30): 7599 - 7609. [Abstract] [Full Text] [PDF]

				P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]

				D. V. Sarkisov and S. S.-H. Wang Order-Dependent Coincidence Detection in Cerebellar Purkinje Neurons at the Inositol Trisphosphate Receptor J. Neurosci., January 2, 2008; 28(1): 133 - 142. [Abstract] [Full Text] [PDF]

				V. Z. Han, Y. Zhang, C. C. Bell, and C. Hansel Synaptic Plasticity and Calcium Signaling in Purkinje Cells of the Central Cerebellar Lobes of Mormyrid Fish J. Neurosci., December 5, 2007; 27(49): 13499 - 13512. [Abstract] [Full Text] [PDF]

				I. C. Duguid, Y. Pankratov, G. W. J. Moss, and T. G. Smart Somatodendritic Release of Glutamate Regulates Synaptic Inhibition in Cerebellar Purkinje Cells via Autocrine mGluR1 Activation J. Neurosci., November 14, 2007; 27(46): 12464 - 12474. [Abstract] [Full Text] [PDF]

				B. E. McKay, J. D. T. Engbers, W. H. Mehaffey, G. R. J. Gordon, M. L. Molineux, J. S. Bains, and R. W. Turner Climbing Fiber Discharge Regulates Cerebellar Functions by Controlling the Intrinsic Characteristics of Purkinje Cell Output J Neurophysiol, April 1, 2007; 97(4): 2590 - 2604. [Abstract] [Full Text] [PDF]

				F. Crepel Developmental Changes in Retrograde Messengers Involved in Depolarization-Induced Suppression of Excitation at Parallel Fiber-Purkinje Cell Synapses in Rodents J Neurophysiol, January 1, 2007; 97(1): 824 - 836. [Abstract] [Full Text] [PDF]

				J. T. Walter and K. Khodakhah The Linear Computational Algorithm of Cerebellar Purkinje Cells J. Neurosci., December 13, 2006; 26(50): 12861 - 12872. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help