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The Journal of Neuroscience, May 31, 2006, 26(22):5888-5893; doi:10.1523/JNEUROSCI.0782-06.2006

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Brief Communications
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus

Elodie Bruel-Jungerman,¹ Sabrina Davis,¹ Claire Rampon,^1,2 and Serge Laroche¹

¹Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8620, Université Paris-Sud, 91405 Orsay, France, and ²Centre de Recherches sur la Cognition Animale, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5169, Université Paul Sabatier, 31062 Toulouse, France

Correspondence should be addressed to Dr. Serge Laroche, Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication, CNRS UMR 8620, Université Paris-Sud, Bâtiment 446, 91405 Orsay, France. Email: serge.laroche{at}ibaic.u-psud.fr

Activity-dependent synaptic plasticity and neurogenesis are two forms of brain plasticity that can participate in functional remodeling of neural networks during the formation of memories. We examined whether long-term potentiation (LTP) of excitatory synaptic transmission, a well characterized form of synaptic plasticity believed to play a critical role in memory formation, can regulate the rate of neurogenesis in the adult rat dentate gyrus in vivo. We first show that induction of LTP at medial perforant path–granule cell synapses stimulates the proliferation of progenitor cells in the dentate gyrus with a consequential long-term persistence of a larger population of surviving newborn cells. Using protocols to examine the effect of LTP on survival, we next show that LTP induction promotes survival of 1- to 2-week-old dentate granule cells. In no case did LTP appear to affect neuronal differentiation. Finally, we show that LTP induces expression of the plasticity-related transcription factor Zif268 in a substantial fraction of 2-week-old but not 1-week-old neurons, suggesting the prosurvival effect of LTP can be observed in the absence of LTP-mediated Zif268 induction in newborn cells. Our results indicate that electrically induced LTP in the dentate gyrus in vivo provides a cellular/molecular environment that favors both proliferation and survival of adult-generated neurons.

Key words: synaptic plasticity; memory; hippocampus; cell survival; Zif268; transcription factor

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Received Feb. 21, 2006; revised April 20, 2006; accepted April 23, 2006.

Correspondence should be addressed to Dr. Serge Laroche, Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication, CNRS UMR 8620, Université Paris-Sud, Bâtiment 446, 91405 Orsay, France. Email: serge.laroche{at}ibaic.u-psud.fr

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