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The Journal of Neuroscience, June 14, 2006, 26(24):6554-6562; doi:10.1523/JNEUROSCI.1543-06.2006

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Behavioral/Systems/Cognitive
Origins of GABA_A and GABA_B Receptor-Mediated Responses of Globus Pallidus Induced after Stimulation of the Putamen in the Monkey

Hitoshi Kita,¹ Satomi Chiken,¹ Yoshihisa Tachibana,² and Atsushi Nambu²

¹Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, Tennessee 38163, and ²Division of System Neurophysiology, National Institute for Physiological Sciences, and School of Life Science, The Graduate University for Advanced Studies, Myodaiji, Okazaki, 444-8585, Japan

Correspondence should be addressed to Hitoshi Kita, Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee–Memphis, 855 Monroe Avenue, Memphis, TN 38163. Email: hkita{at}utmem.edu

The external and internal segments of the pallidum (GPe and GPi) receive heavy GABAergic innervations from the neostriatum, an input nucleus of the basal ganglia. The GPe neurons provide another major GABAergic innervation to the GPe itself and GPi. Although these GABAergic inputs are considered to play key roles in controlling the level and pattern of firing activity of pallidal neurons in both normal and pathophysiological conditions, these inputs have not been well characterized in vivo. Here, we characterized the responses of pallidal neurons to single and burst stimulation of the putamen (Put) in awake monkeys. Unit recordings in combination with local infusion of drugs and a chemical blockade of the subthalamic nucleus (STN), the major origin of excitatory afferents, revealed the following. Under STN blockade, the duration of single Put stimulation induced gabazine (a GABA_A antagonist)-sensitive responses differed greatly in the GPe (400 ms long) and in the GPi (60 ms long). Burst stimulation of the Put induced CGP55845 [(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl}(phenylmethyl)phosphinic acid] (a GABA_B antagonist)-sensitive responses in the GPe and GPi. However, the data suggested that the origin of the GABA_B responses was the GPe, not the Put. Local CGP55845 application increased the spontaneous firing of GPe and GPi neurons, suggesting that GABA released from the axons of GPe neurons effectively activates GABA_B receptors in the GPe and GPi and contributes significantly to the control of the level of neuronal activity.

Key words: globus pallidus; putamen; unit recording; GABA_A responses; GABA_B responses; awake monkey

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Received Nov. 22, 2005; revised May 10, 2006; accepted May 12, 2006.

Correspondence should be addressed to Hitoshi Kita, Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee–Memphis, 855 Monroe Avenue, Memphis, TN 38163. Email: hkita{at}utmem.edu

This article has been cited by other articles:

				M. A. Kliem, N. T. Maidment, L. C. Ackerson, S. Chen, Y. Smith, and T. Wichmann Activation of Nigral and Pallidal Dopamine D1-Like Receptors Modulates Basal Ganglia Outflow in Monkeys J Neurophysiol, September 1, 2007; 98(3): 1489 - 1500. [Abstract] [Full Text] [PDF]

				H. Kita, S. Chiken, Y. Tachibana, and A. Nambu Serotonin Modulates Pallidal Neuronal Activity in the Awake Monkey J. Neurosci., January 3, 2007; 27(1): 75 - 83. [Abstract] [Full Text] [PDF]

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