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The Journal of Neuroscience, July 5, 2006, 26(27):7131-7134; doi:10.1523/JNEUROSCI.1801-06.2006
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Mini-Reviews
RNA Trafficking and Local Protein Synthesis in Dendrites: An Overview
Kelsey C. Martin1 andR. Suzanne Zukin2 1Department of Psychiatry and Biobehavioral Sciences, Department of Biological Chemistry, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095-1761, and 2Department Neuroscience, Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461
Correspondence should be addressed to either of the following: Dr. R. Suzanne Zukin, Department of Neuroscience, Rose F. Kennedy Center, Room 602, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, Email: zukin{at}aecom.yu.edu; or Dr. Kelsey C. Martin, Department of Psychiatry and Biobehavioral Sciences and Department of Biological Chemistry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095-1761, kcmartin{at}mednet.ucla.edu
It is now widely accepted that mRNAs localize to dendrites and that translation of these mRNAs is regulated in response to neuronal activity. Recent studies have begun to reveal the underpinnings of these processes and to underscore the importance of local protein synthesis to synaptic remodeling and plasticity.
When Steward and Levy (1982) first reported their observation of polyribosomes at the base of spines, the prevailing view was that all proteins were synthesized in the cell body and then transported to distal compartments of neurons. Steward and Levy's discovery, however, raised the intriguing possibility that mRNAs could be transported to synapses and locally translated in response to synaptic stimulation. This provided an elegant mechanism for spatially restricting gene expression within the neuron, such that individual synapses could independently regulate their morphology and efficacy, in a persistent, protein synthesis-dependent manner, in response to specific stimuli. It is now widely accepted that mRNAs do localize to dendrites and that translation of these mRNAs contributes to synaptic plasticity. As is evident from the collection of Mini-Reviews on dendritic protein synthesis in this issue of The Journal of Neuroscience, the field has evolved to focus on a series of key questions, including the following: (1) what mRNAs are present in dendrites? (2) How are these mRNAs transported from the nucleus into the dendrite? (3) How is translation of these mRNAs regulated by neuronal activity? and (4) What is the function of local translation of specific transcripts? In this brief introductory overview, we will consider each of these questions in turn.
Key words: synaptic plasticity; mRNA trafficking; dendrites; transcriptional regulation; excitatory synapses; dendritic localization
Received April 27, 2006; revised May 26, 2006; accepted May 26, 2006.
Correspondence should be addressed to either of the following: Dr. R. Suzanne Zukin, Department of Neuroscience, Rose F. Kennedy Center, Room 602, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, Email: zukin{at}aecom.yu.edu; or Dr. Kelsey C. Martin, Department of Psychiatry and Biobehavioral Sciences and Department of Biological Chemistry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095-1761, kcmartin{at}mednet.ucla.edu
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