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The Journal of Neuroscience, July 5, 2006, 26(27):7135-7138; doi:10.1523/JNEUROSCI.1795-06.2006

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Mini-Reviews
RNA-Binding Proteins: A Lesson in Repression

David G. Wells

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520

Correspondence should be addressed to David G. Wells, Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, KBT 226, Box 208103, New Haven, CT 06520-8103. Email: david.wells{at}yale.edu

Regulation of protein expression in neurons by controlling not only when, but where, mRNAs are translated is likely to play an important role in neuronal function. In this review I focus on the mRNA-binding proteins that control mRNA translation in neurons and how they may participate in local, synaptodendritic protein synthesis.

Key words: synaptic plasticity; FMRP; mRNA translation; CPEB; ZBP; translation initiation

Received April 27, 2006; revised May 24, 2006; accepted May 24, 2006.

Correspondence should be addressed to David G. Wells, Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, KBT 226, Box 208103, New Haven, CT 06520-8103. Email: david.wells{at}yale.edu




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