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The Journal of Neuroscience, July 5, 2006, 26(27):7139-7142; doi:10.1523/JNEUROSCI.1821-06.2006

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Mini-Reviews
mRNA Transport in Dendrites: RNA Granules, Motors, and Tracks

Nobutaka Hirokawa

Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo 113-0033, Japan

Correspondence should be addressed to Dr. Nobutaka Hirokawa, Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo 113-0033, Japan. Email: hirokawa{at}m.u-tokyo.ac.jp

The targeting of mRNAs to neuronal dendrites is an important protein sorting mechanism. Recent studies have revealed that mRNAs are transported by molecular motors. The kinesin superfamily protein KIF5 transports mRNAs such as calcium/calmodulin-dependent kinase II (CaMKII) and Arc mRNAs along microtubules in large granules containing proteins involved in RNA transport, protein synthesis, RNA helicases, heterogeneous nuclear ribonucleoproteins (hnRNPs), and RNA-associated proteins. This transport is fundamental to local protein synthesis and to the regulation of neuronal function.

Key words: microfilament; tubulin; transport; granule; RNA trafficking; intracellular signaling; cytoskeleton

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Received April 29, 2006; revised May 26, 2006; accepted May 26, 2006.

Correspondence should be addressed to Dr. Nobutaka Hirokawa, Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo 113-0033, Japan. Email: hirokawa{at}m.u-tokyo.ac.jp

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