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The Journal of Neuroscience, July 5, 2006, 26(27):7147-7150; doi:10.1523/JNEUROSCI.1797-06.2006

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Mini-Reviews
Current Advances in Local Protein Synthesis and Synaptic Plasticity

Brad E. Pfeiffer and Kimberly M. Huber

Center for Basic Neuroscience, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390

Correspondence should be addressed to Dr. Kimberly M. Huber, Center for Basic Neuroscience, Utah Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9111. Email: Kimberly.Huber{at}UTSouthwestern.edu

Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation. Current research indicates that the specificity by which new proteins participate in either LTP or LTD may be determined in part by specific RNA-binding proteins as well as activity-dependent capture.

Key words: LTP; ERK; LTD; protein synthesis; fragile X mental retardation protein; 4EBP

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Received April 27, 2006; revised May 28, 2006; accepted May 28, 2006.

Correspondence should be addressed to Dr. Kimberly M. Huber, Center for Basic Neuroscience, Utah Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9111. Email: Kimberly.Huber{at}UTSouthwestern.edu

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