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The Journal of Neuroscience, July 5, 2006, 26(27):7156-7162; doi:10.1523/JNEUROSCI.0906-06.2006

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Behavioral/Systems/Cognitive
The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation

Y. M. Lisa Chuah,¹ Vinod Venkatraman,¹ David F. Dinges,² and Michael W. L. Chee¹

¹Cognitive Neuroscience Laboratory, Singapore Health Services, Singapore, 169611, and ²Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021

Correspondence should be addressed to Dr. Michael W. L. Chee, Cognitive Neuroscience Laboratory, Singapore Health Services, 7 Hospital Drive, #01-11, Block B, SingHealth Research Facilities, Singapore, 169611. Email: mchee{at}pacific.net.sg

Sleep deprivation results in the loss of our ability to suppress a prepotent response. The extent of decline in this executive function varies across individuals. Here, we used functional magnetic resonance imaging to study the neural correlates of sleep deprivation-induced differences in inhibitory efficiency. Participants performed a go/no-go task after normal sleep and after 24 h of total sleep deprivation. Regardless of the extent of change in inhibitory efficiency, sleep deprivation lowered go/no-go sustained, task-related activation of the ventral and anterior prefrontal (PFC) regions bilaterally. However, individuals better able to maintain inhibitory efficiency after sleep deprivation could be distinguished by lower stop-related, phasic activation of the right ventral PFC during rested wakefulness. These persons also showed a larger rise in such activation both here and in the right insula after sleep deprivation relative to those whose inhibitory efficiency declined.

Key words: go/no-go; inhibition; error monitoring; compensation; functional neuroimaging; prefrontal cortex

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Received March 1, 2006; revised May 26, 2006; accepted May 26, 2006.

Correspondence should be addressed to Dr. Michael W. L. Chee, Cognitive Neuroscience Laboratory, Singapore Health Services, 7 Hospital Drive, #01-11, Block B, SingHealth Research Facilities, Singapore, 169611. Email: mchee{at}pacific.net.sg

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