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The Journal of Neuroscience, July 12, 2006, 26(28):7362-7367; doi:10.1523/JNEUROSCI.1257-06.2006

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Brief Communications
TASK-Like Conductances Are Present within Hippocampal CA1 Stratum Oriens Interneuron Subpopulations

Christine L. Torborg,¹ Allison P. Berg,² Brian W. Jeffries,¹ Douglas A. Bayliss,² and Chris J. McBain¹

¹Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, and ²Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908

Correspondence should be addressed to Christine L. Torborg, Laboratory on Cellular and Synaptic Neurophysiology, Building 35, Room 3C907, National Institute of Child Health and Human Development–Laboratory on Cellular and Synaptic Neurophysiology, Bethesda, MD 20892. Email: torborgc{at}mail.nih.gov

TASK-1 (KCNK3) and TASK-3 (KCNK9) are members of the two-pore domain potassium channel family and form either homomeric or heteromeric open-rectifier (leak) channels. Recent evidence suggests that these channels contribute to the resting potential and input resistance in several neuron types, including hippocampal CA1 pyramidal cells. However, the evidence for TWIK-related acid-sensitive potassium (TASK)-like conductances in inhibitory interneurons is less clear, and mRNA expression has suggested that TASK channels are expressed in only a subpopulation of interneurons. Here we use immunocytochemistry to demonstrate prominent TASK-3 protein expression in both parvalbumin-positive- and a subpopulation of glutamic acid decarboxylase (GAD)67-positive interneurons. In addition, a TASK-like current (modulated by both pH and bupivacaine) was detected in 30–50% of CA1 stratum oriens interneurons of various morphological classes. In most neurons, basic shifts in pH had a larger effect on the TASK-like current than acidic, suggesting that the current is mediated by TASK-1/TASK-3 heterodimers. These data suggest that TASK-like conductances are more prevalent in inhibitory interneurons than previously supposed.

Key words: potassium channels; interneurons; TASK; KCNK; hippocampus; inhibition

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Received March 23, 2006; revised June 6, 2006; accepted June 6, 2006.

Correspondence should be addressed to Christine L. Torborg, Laboratory on Cellular and Synaptic Neurophysiology, Building 35, Room 3C907, National Institute of Child Health and Human Development–Laboratory on Cellular and Synaptic Neurophysiology, Bethesda, MD 20892. Email: torborgc{at}mail.nih.gov

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