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The Journal of Neuroscience, January 18, 2006, 26(3):1057-1060; doi:10.1523/JNEUROSCI.4177-05.2006

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BRIEF COMMUNICATION
Restoration of Neuronal Plasticity by a Phosphodiesterase Type 1 Inhibitor in a Model of Fetal Alcohol Exposure

Alexandre E. Medina, Thomas E. Krahe, and Ary S. Ramoa {dagger}

Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298

Although some studies showed the efficacy of phosphodiesterase (PDE) inhibitors as neuronal plasticity enhancers, little is known about the effectiveness of these drugs to improve plasticity in cases of mental retardation. Fetal alcohol syndrome (FAS) is the leading cause of mental retardation in the western world. Using a combination of electrophysiological and optical imaging techniques, we show here that vinpocetine, a PDE type I inhibitor, restores ocular dominance plasticity in the ferret model of fetal alcohol exposure. Our finding should contribute to a better understanding and treatment of cognitive deficits associated with mental disorders, such as FAS.

Key words: alcohol; ocular dominance plasticity; visual development; ferret; monocular deprivation; optical imaging; neocortex development; fetal alcohol syndrome

Received Sep 30, 2005; revised December 12, 2005; accepted December 14, 2005.






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