QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 2, 2006, 26(31):8168-8175; doi:10.1523/JNEUROSCI.2002-06.2006

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (20) Citing Articles via Google Scholar Google Scholar Articles by Uhlhaas, P. J. Articles by Rodriguez, E. Search for Related Content PubMed PubMed Citation Articles by Uhlhaas, P. J. Articles by Rodriguez, E.

 Previous Article  |  Next Article 

Neurobiology of Disease
Dysfunctional Long-Range Coordination of Neural Activity during Gestalt Perception in Schizophrenia

Peter J. Uhlhaas,^1,2 David E. J. Linden,^1,2,3 Wolf Singer,^1,4 Corinna Haenschel,^1,2 Michael Lindner,² Konrad Maurer,² and Eugenio Rodriguez^1,4

¹Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt am Main, 60528, Germany, ²Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt am Main, 60528, Germany, ³School of Psychology, University of Wales, Bangor LL57 2AS, United Kingdom, and ⁴Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, Frankfurt am Main, 60438, Germany

Correspondence should be addressed to Dr. Peter J. Uhlhaas, Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt am Main, 60590, Germany. Email: uhlhaas{at}mpih-frankfurt.mpg.de

Recent theoretical and empirical research on schizophrenia converges on the notion that core aspects of the pathophysiology of the disorder may arise from a dysfunction in the coordination of distributed neural activity. Synchronization of neural responses in the -band (15–30 Hz) and -band range (30–80 Hz) has been implicated as a possible neural substrate for dysfunctional coordination in schizophrenia. To test this hypothesis, we examined the electroencephalography (EEG) activity in 19 patients with a Diagnostic and Statistical Manual of Mental Disorder, edition IV criteria, diagnosis of schizophrenia and 19 healthy control subjects during a Gestalt perception task. EEG data were analyzed for phase synchrony and induced spectral power as an index of neural synchronization. Schizophrenia patients were impaired significantly in the detection of images that required the grouping of stimulus elements into coherent object representations. This deficit was accompanied by longer reaction times in schizophrenia patients. Deficits in Gestalt perception in schizophrenia patients were associated with reduced phase synchrony in the -band (20–30 Hz), whereas induced spectral power in the -band (40–70 Hz) was mainly intact. Our findings suggest that schizophrenia patients are impaired in the long-range synchronization of neural responses, which may reflect a core deficit in the coordination of neural activity and underlie the specific cognitive dysfunctions associated with the disorder.

Key words: schizophrenia; long-range coordination; synchronization; Gestalt perception; electroencephalography; -oscillations

---

Received March 10, 2006; revised May 29, 2006; accepted June 30, 2006.

Correspondence should be addressed to Dr. Peter J. Uhlhaas, Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt am Main, 60590, Germany. Email: uhlhaas{at}mpih-frankfurt.mpg.de

This article has been cited by other articles:

				P. L. Tierney, A. M. Thierry, J. Glowinski, J. M. Deniau, and Y. Gioanni Dopamine Modulates Temporal Dynamics of Feedforward Inhibition in Rat Prefrontal Cortex In Vivo Cereb Cortex, October 1, 2008; 18(10): 2251 - 2262. [Abstract] [Full Text] [PDF]

				A. K. Roopun, M. O. Cunningham, C. Racca, K. Alter, R. D. Traub, and M. A. Whittington Region-Specific Changes in Gamma and Beta2 Rhythms in NMDA Receptor Dysfunction Models of Schizophrenia Schizophr Bull, September 1, 2008; 34(5): 962 - 973. [Abstract] [Full Text] [PDF]

				P. J. Uhlhaas, C. Haenschel, D. Nikolic, and W. Singer The Role of Oscillations and Synchrony in Cortical Networks and Their Putative Relevance for the Pathophysiology of Schizophrenia Schizophr Bull, September 1, 2008; 34(5): 927 - 943. [Abstract] [Full Text] [PDF]

				G. Gonzalez-Burgos and D. A. Lewis GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia Schizophr Bull, September 1, 2008; 34(5): 944 - 961. [Abstract] [Full Text] [PDF]

				B. J. Roach and D. H. Mathalon Event-Related EEG Time-Frequency Analysis: An Overview of Measures and An Analysis of Early Gamma Band Phase Locking in Schizophrenia Schizophr Bull, September 1, 2008; 34(5): 907 - 926. [Abstract] [Full Text] [PDF]

				D. Dickinson and P. D. Harvey Systemic Hypotheses for Generalized Cognitive Deficits in Schizophrenia: A New Take on An Old Problem Schizophr Bull, August 9, 2008; (2008) sbn097v1. [Abstract] [Full Text] [PDF]

				F. Ferrarelli, M. Massimini, M. J. Peterson, B. A. Riedner, M. Lazar, M. J. Murphy, R. Huber, M. Rosanova, A. L. Alexander, N. Kalin, et al. Reduced Evoked Gamma Oscillations in the Frontal Cortex in Schizophrenia Patients: A TMS/EEG Study Am J Psychiatry, August 1, 2008; 165(8): 996 - 1005. [Abstract] [Full Text] [PDF]

				G. K. Thaker Neurophysiological Endophenotypes Across Bipolar and Schizophrenia Psychosis Schizophr Bull, July 1, 2008; 34(4): 760 - 773. [Abstract] [Full Text] [PDF]

				S. Hirano, Y. Hirano, T. Maekawa, C. Obayashi, N. Oribe, T. Kuroki, S. Kanba, and T. Onitsuka Abnormal Neural Oscillatory Activity to Speech Sounds in Schizophrenia: A Magnetoencephalography Study J. Neurosci., May 7, 2008; 28(19): 4897 - 4903. [Abstract] [Full Text] [PDF]

				D. Vierling-Claassen, P. Siekmeier, S. Stufflebeam, and N. Kopell Modeling GABA Alterations in Schizophrenia: A Link Between Impaired Inhibition and Altered Gamma and Beta Range Auditory Entrainment J Neurophysiol, May 1, 2008; 99(5): 2656 - 2671. [Abstract] [Full Text] [PDF]

				C. I. Buia and P. H. Tiesinga Role of Interneuron Diversity in the Cortical Microcircuit for Attention J Neurophysiol, May 1, 2008; 99(5): 2158 - 2182. [Abstract] [Full Text] [PDF]

				C. Haenschel, R. A. Bittner, F. Haertling, A. Rotarska-Jagiela, K. Maurer, W. Singer, and D. E. J. Linden Contribution of Impaired Early-Stage Visual Processing to Working Memory Dysfunction in Adolescents With Schizophrenia: A Study With Event-Related Potentials and Functional Magnetic Resonance Imaging Arch Gen Psychiatry, November 1, 2007; 64(11): 1229 - 1240. [Abstract] [Full Text] [PDF]

				O. van der Stelt and A. Belger Application of Electroencephalography to the Study of Cognitive and Brain Functions in Schizophrenia Schizophr Bull, July 1, 2007; 33(4): 955 - 970. [Abstract] [Full Text] [PDF]

				R. E. Gur, M. S. Keshavan, and S. M. Lawrie Deconstructing Psychosis With Human Brain Imaging Schizophr Bull, July 1, 2007; 33(4): 921 - 931. [Abstract] [Full Text] [PDF]

				P. J. Uhlhaas and A. L. Mishara Perceptual Anomalies in Schizophrenia: Integrating Phenomenology and Cognitive Neuroscience Schizophr Bull, January 1, 2007; 33(1): 142 - 156. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help