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The Journal of Neuroscience, August 2, 2006, 26(31):8168-8175; doi:10.1523/JNEUROSCI.2002-06.2006
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Neurobiology of Disease
Dysfunctional Long-Range Coordination of Neural Activity during Gestalt Perception in Schizophrenia
Peter J. Uhlhaas,1,2 David E. J. Linden,1,2,3 Wolf Singer,1,4 Corinna Haenschel,1,2 Michael Lindner,2 Konrad Maurer,2 andEugenio Rodriguez1,4 1Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt am Main, 60528, Germany, 2Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt am Main, 60528, Germany, 3School of Psychology, University of Wales, Bangor LL57 2AS, United Kingdom, and 4Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, Frankfurt am Main, 60438, Germany
Correspondence should be addressed to Dr. Peter J. Uhlhaas, Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt am Main, 60590, Germany. Email: uhlhaas{at}mpih-frankfurt.mpg.de
Recent theoretical and empirical research on schizophrenia converges on the notion that core aspects of the pathophysiology of the disorder may arise from a dysfunction in the coordination of distributed neural activity. Synchronization of neural responses in the
-band (15–30 Hz) and
-band range (30–80 Hz) has been implicated as a possible neural substrate for dysfunctional coordination in schizophrenia. To test this hypothesis, we examined the electroencephalography (EEG) activity in 19 patients with a Diagnostic and Statistical Manual of Mental Disorder, edition IV criteria, diagnosis of schizophrenia and 19 healthy control subjects during a Gestalt perception task. EEG data were analyzed for phase synchrony and induced spectral power as an index of neural synchronization. Schizophrenia patients were impaired significantly in the detection of images that required the grouping of stimulus elements into coherent object representations. This deficit was accompanied by longer reaction times in schizophrenia patients. Deficits in Gestalt perception in schizophrenia patients were associated with reduced phase synchrony in the
Key words: schizophrenia; long-range coordination; synchronization; Gestalt perception; electroencephalography;
Received March 10, 2006; revised May 29, 2006; accepted June 30, 2006.
Correspondence should be addressed to Dr. Peter J. Uhlhaas, Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt am Main, 60590, Germany. Email: uhlhaas{at}mpih-frankfurt.mpg.de
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