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The Journal of Neuroscience, August 9, 2006, 26(32):8352-8359; doi:10.1523/JNEUROSCI.5222-05.2006

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Behavioral/Systems/Cognitive
The Long and the Short of It: Relational Memory Impairments in Amnesia, Even at Short Lags

Deborah E. Hannula,¹ Daniel Tranel,² and Neal J. Cohen^1,3

¹University of Illinois, Urbana-Champaign, Illinois 61801, ²University of Iowa, Iowa City, Iowa 52242, and ³Washington University, St. Louis, Missouri 63130

Correspondence should be addressed to Deborah Hannula, 1544 Newton Court, Center for Neuroscience, University of California, Davis, CA 95616. Email: dehannula{at}ucdavis.edu

Classic studies of amnesia led to characterizations of hippocampal function emphasizing involvement in long-term memory rather than short-term (or working) memory. In two experiments, we show that when memory for relations among co-occurring items is tested, hippocampal amnesia results in a deficit even at very short lags. Hence, we find evidence for hippocampal involvement in relational memory, even at short lags normally considered the province of working memory.

Key words: memory; amnesia; hippocampus; relational memory; long-term memory; short-term memory; human

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Received Dec. 7, 2005; revised June 28, 2006; accepted June 29, 2006.

Correspondence should be addressed to Deborah Hannula, 1544 Newton Court, Center for Neuroscience, University of California, Davis, CA 95616. Email: dehannula{at}ucdavis.edu

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