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The Journal of Neuroscience, September 6, 2006, 26(36):9135-9141; doi:10.1523/JNEUROSCI.4869-05.2006

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Development/Plasticity/Repair
High Levels of New Neuron Addition Persist When the Sensitive Period for Song Learning Is Experimentally Prolonged

Linda Wilbrecht,1,4 Heather Williams,2 Nidhi Gangadhar,1,3 and Fernando Nottebohm1

1Laboratory of Animal Behavior, Rockefeller University, New York, New York 10021, 2Biology Department, Williams College, Williamstown, Massachusetts 01267, 3Department of Biological Sciences, Columbia University, New York, New York 10027, and 4Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724

Correspondence should be addressed to Dr. Linda Wilbrecht, 1 Bungtown Road, Svoboda Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724. Email: wilbrech{at}cshl.org

Socially reared zebra finch males imitate a song they hear during posthatching days 30–65; during this time, many new neurons are added to the high vocal center (HVC), a forebrain nucleus necessary for the production of learned song. New neuron addition drops sharply after day 65, and no new songs are imitated. In contrast, male zebra finches reared in isolation from other males have more variable songs at day 65 and thereafter can still imitate new sounds (Eales, 1985). We show that, in isolate birds, a greater number of new neurons continues to be added to HVC during the next 85 d, and this number correlates with syllable variability. We suggest that new neuron addition and turnover facilitate song change and that this effect lingers when an expected learning event is delayed.

Key words: neurogenesis; learning and memory; BrdU; birdsong; neuroethology; deprivation

Received Nov. 11, 2005; revised June 29, 2006; accepted July 25, 2006.

Correspondence should be addressed to Dr. Linda Wilbrecht, 1 Bungtown Road, Svoboda Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724. Email: wilbrech{at}cshl.org




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Genomic resources for songbird research and their use in characterizing gene expression during brain development
PNAS, April 17, 2007; 104(16): 6834 - 6839.
[Abstract] [Full Text] [PDF]


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