QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 25, 2006, 26(4):1247-1259; doi:10.1523/JNEUROSCI.3100-05.2006

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Spors, H. Articles by Friedrich, R. W. Search for Related Content PubMed PubMed Citation Articles by Spors, H. Articles by Friedrich, R. W.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Temporal Dynamics and Latency Patterns of Receptor Neuron Input to the Olfactory Bulb

Hartwig Spors,^1 * Matt Wachowiak,^3,4 * Lawrence B. Cohen,³ and Rainer W. Friedrich²

¹WIN Group of Olfactory Dynamics and ²Department of Biomedical Optics, Max-Planck-Institut für Medizinische Forschung, D-69120 Heidelberg, Germany, ³Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, and ⁴Department of Biology, Boston University, Boston, Massachusetts 02215

Correspondence should be addressed to Hartwig Spors, WIN Group of Olfactory Dynamics, Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany. Email: spors{at}mpimf-heidelberg.mpg.de

Odorants are first represented in the brain by distributed patterns of activity in the olfactory bulb (OB). Although neurons downstream of sensory inputs respond to odorants with temporally structured activity, sensory inputs to glomeruli are typically described as static maps. Here, we imaged the temporal dynamics of receptor neuron input to the OB with a calcium-sensitive dye in the olfactory receptor nerve terminals in anesthetized mice. We found that diverse, glomerulus- and odorant-dependent temporal dynamics are present even at this initial input stage. Instantaneous spatial patterns of receptor input to glomeruli changed both within and between respiration cycles. Glomerular odorant responses differed in amplitude, latency, rise time, and degree of modulation by sniffing in an odorant-specific manner. Pattern dynamics within the first respiration cycle recurred in a similar manner during consecutive cycles. When sniff rate was increased artificially, pattern dynamics were preserved in the first sniff but were attenuated during subsequent sniffs. Temporal response properties were consistent across individuals on a coarse regional scale and on a fine scale of individual glomeruli. Latency and magnitude of glomerular inputs were only weakly correlated and might therefore convey independent odorant information. These data demonstrate that glomerular maps of primary sensory input to the OB are temporally dynamic. These dynamics may contribute to the representation of odorant information and affect information processing in the central olfactory system of rodents.

Key words: olfaction; sensory coding; imaging; in vivo; mouse; maps

---

Received July 27, 2005; revised Nov. 24, 2005; accepted Dec. 13, 2005.

Correspondence should be addressed to Hartwig Spors, WIN Group of Olfactory Dynamics, Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany. Email: spors{at}mpimf-heidelberg.mpg.de

This article has been cited by other articles:

				N. Pirez and M. Wachowiak In Vivo Modulation of Sensory Input to the Olfactory Bulb by Tonic and Activity-Dependent Presynaptic Inhibition of Receptor Neurons J. Neurosci., June 18, 2008; 28(25): 6360 - 6371. [Abstract] [Full Text] [PDF]

				D. W. Wesson, T. N. Donahou, M. O. Johnson, and M. Wachowiak Sniffing Behavior of Mice during Performance in Odor-Guided Tasks Chem Senses, June 5, 2008; (2008) bjn029v1. [Abstract] [Full Text] [PDF]

				J. V. Verhagen and D. B. Katz More Time to Taste. Focus on "Variability in Responses and Temporal Coding of Tastants of Similar Quality in the Nucleus of the Solitary Tract of the Rat" J Neurophysiol, February 1, 2008; 99(2): 413 - 414. [Full Text] [PDF]

				B. Slotnick Response Accuracy and Odor Sampling Time in Mice Trained to Discriminate between Enantiomers of Carvone and Those of Terpinen-4-ol Chem Senses, September 1, 2007; 32(7): 721 - 725. [Abstract] [Full Text] [PDF]

				E. Chaigneau, P. Tiret, J. Lecoq, M. Ducros, T. Knopfel, and S. Charpak The Relationship between Blood Flow and Neuronal Activity in the Rodent Olfactory Bulb J. Neurosci., June 13, 2007; 27(24): 6452 - 6460. [Abstract] [Full Text] [PDF]

				B. Slotnick Odor-Sampling Time of Mice under Different Conditions Chem Senses, June 1, 2007; 32(5): 445 - 454. [Abstract] [Full Text] [PDF]

				R. L. Rennaker, C.-F. F. Chen, A. M. Ruyle, A. M. Sloan, and D. A. Wilson Spatial and Temporal Distribution of Odorant-Evoked Activity in the Piriform Cortex J. Neurosci., February 14, 2007; 27(7): 1534 - 1542. [Abstract] [Full Text] [PDF]

				B. Slotnick Olfactory Performance of Rats after Selective Deafferentation of the Olfactory Bulb by 3-Methyl Indole Chem Senses, February 1, 2007; 32(2): 173 - 181. [Abstract] [Full Text] [PDF]

				K. McBride and B. Slotnick Discrimination between the Enantiomers of Carvone and of Terpinen-4-ol Odorants in Normal Rats and Those with Lesions of the Olfactory Bulbs J. Neurosci., September 27, 2006; 26(39): 9892 - 9901. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help